目录
2013-2016 美国阿克伦大学 高分子科学系 博士后
2004-2008 中国科学技术大学 化学系 学士学位
广东省生物农药工程技术研究中心 副主任
期刊Advanced Agrochem 青年编委
中国农药发展与应用协会生物农药专业委员会 办公室主任
广东省化工学会农药专业委员会 委员
广东省化工学会 会员
1. 国家自然科学基金青年项目，"基于超分子作用的环糊精类导向农药载体的设计、合成及转运性能研究"，2018-2020，主持，23万。
2. 国家重点研发计划，“化学肥料和农药减施增效综合技术研发”试点专项"靶标导向的分子设计与天然产物结构多样性衍生"，子课题“导向载体-农药复合结构设计与合成”，2017-2020，主持，5万。
3. 广州市科技计划，"基于超分子结构的农药导向助剂的设计合成“，2020-2023，主持，20万。
4. 广东省重点领域研发计划“精准农业及生态绿色技术”重点专项，“绿色高效农业投入品缓控释材料制备关键技术与应用”项目，2022-2025，参与（排名第2）。
发表论文：
1. Shuai Yang, Jiahong Tang, Benjie Li, Guangkai Yao*, Hongxiang Peng, Chunmei Pu, Chen Zhao* and Hanhong Xu*. Rational design of insecticidal isoxazolines containing sulfonamide or sulfinamide structure as antagonists of GABA receptors with reduced toxicities to honeybee and zebrafish. Journal of Agricultural and Food Chemistry, 2023, 71, 39, 14211–14220.
2. Shuai Yang, Jiahong Tang, Hongxiang Peng, Chunmei Pu, Shuting Fan, Chen Zhao*, and Hanhong Xu*. Discovery of novel thiazolyl anthranilic diamide derivatives as insecticidal candidates. Pest Management Science, 2023, 79, 12, 5260-5269.
3. Shuai Yang, Benjie Li, Jiahong Tang, Hongxiang Peng, Chunmei Pu, Chen Zhao* and Hanhong Xu*. Structural optimization based on 4, 5-dihydropyrazolo [1, 5-a] quinazoline scaffold for improved insecticidal activities. Pesticide Biochemistry and Physiology, 2023, 105533.
4. Guangkai Yao, Shuo Han, Yingjie Wen, Yuyan Xiao, Chen Zhao,* Hanhong Xu.* Design, synthesis, insecticidal activities and translocation of amino acid–tralopyril conjugates as vectorizing agrochemicals. Pest Management Science, 2023, 79, 4018-4024.
5. Tianhao Jia, Nianyou Pan, Xiangmin Song, Yongchao Gao, Zhixiang Zhang, Hanhong Xu*, and Chen Zhao.* Preparation and characterization of insecticide/calix[4]arene complexes and their enhanced insecticidal activities against Plutella xylostella. Journal of Agricultural and Food Chemistry. 2023, 71, 14, 5576–5584.
6. Guangkai Yao, Mengfan Wang, Benjie Li, Hongxiang Peng, Shuai Yang, Chen Zhao,* Hanhong Xu.* Design, synthesis, and biological activity of novel spiro-pyrazolo[1,5-a]quinazolines derivatives as potential insecticides. Pest Management Science, 2023, 79, 1164-1174.
7. Ruiquan Hou, Chao Li, Yuting Tan, Yongqing, Wang, Suqing Huang, Chen Zhao*, Zhixiang Zhang*. Eco-friendly O-carboxymethyl chitosan base chlorfenapyr nanopesticide for effective pest control and reduced toxicity to honey bees. International Journal of Biological Macromolecules, 2023, 224, 972-983.
8. Ruiquan Hou, Jingtong Zhou, Zixia Song, Ning Zhang, Suqing Huang, Amir E. Kaziem, Chen Zhao*, Zhixiang, Zhang*. pH-responsive λ-cyhalothrin nanopesticides for effective pest control and reduced toxicity to Harmonia axyridis. Carbohydrate Polymers, 2023, 302, 120373.
9. Tianhao Jia, Chunmei Pu, Tianyi Qin*, Bin Liu, Guangkai Yao, Zhiqing Xun, Bingfeng Wang, Yongqing Tian, Zhixiang Zhang*, Hanhong Xu*, and Chen Zhao*. Azocalixarene-based supramolecular system for the detection of paraquat via an improved indicator displacement assay. Journal of Agricultural and Food Chemistry. 2022, 70(50), 15981–15989.
10. Shuai Yang, Hongxiang Peng, Jiahong Tang, Shuting Fan, Chen Zhao, Hanhong Xu, and Guangkai Yao*. Discovery of novel N-pyridylpyrazole thiazole derivatives as insecticide leads. Agronomy, 2022, 12, 2472.
11. Tianyi Qin, Xiongfei Zhao, Taoyuze Lv, Guangkai Yao, Zhongyong Xu, Lei Wang, Chen Zhao,* Hanhong Xu,* Bin Liu,* and Xiaojun Peng. General method for pesticide recognition using albumin-based host-guest ensembles. ACS sensors, 2022, 7(7), 2020–2027.
12. Tianyi Qin*, Xiongfei Zhao, Tianhao Jia, Shufan Si, Zhongyong Xu, Bin Liu, Hanhong Xu*, and Chen Zhao*. A surfactant-assisted approach enables the fluorescence tracking of benfluralin in plants. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 121517.
13. Shuai Yang, Hongxiang Peng, Jinyi Zhu, Chen Zhao,* Hanhong Xu.* Design, synthesis, insecticidal activities, and molecular docking of novel pyridylpyrazolo carboxylate derivatives. Journal of Heterocyclic Chemistry, 2022, 59(8), 1366-1375.
14. Tianyi Qin, Xiongfei Zhao, Tianhao Jia, Xinfeng Du, Taoyuze Lv, Yongqing Tian, Zhixiang Zhang, Bin Liu,* Hanhong Xu,* Chen Zhao.* A novel protein-based supramolecular recognition approach for ratiometric fluorescence detection of fipronil. Sensors and Actuators B: Chemical, 2022, 369, 132358.
15. Bingfeng Wang, Chen Yang, Xunyuan Jiang, Yingjie Wen, Yongqing Tian, Chen Zhao,* and Hanhong Xu*. Design of new glycosyl-O-fipronil conjugates with improved hydrolysis efficiency assisted by molecular simulations. Pest Management Science, 2022, 78(6), 2667-2678.
16. Weijing Zhao, Shijie Zheng, Jinwen Zou, Yunshi Liang, Chen Zhao* and Hanhong Xu*. Synthesis of novel pesticidal N,N’-disubstituted sulfamide derivatives using sulfur(VI) fluorine exchange click reaction. Journal of Agricultural and Food Chemistry 2021, 69, 5798−5803.
17. Tianyi Qin, Bin Liu, Zhongyong Xu, Guangkai Yao, Hanhong Xu, Chen Zhao*. Flavonol-based small-molecule fluorescent probes. Sensors and Actuators B: Chemical, 2021, 336, 129718.
18. Shuai Yang, Qiuqing Lai, Fengwen Lai, Xunyuan Jiang, Chen Zhao*, Hanhong Xu*. Design, synthesis, and insecticidal activities of novel 5-substituted 4,5-dihydropyrazolo[1,5-a]quinazoline derivatives. Pest Management Science 2021, 77, 1013-1022.
19. Tianyi Qin, Bin Liu,* Bing Du, Yingying Huang, Guangkai Yao, Zhiqing Xun, Hanhong Xu* and Chen Zhao*. Solvatofluorochromic flavonoid dyes with enlarged transition dipole moments enable the ratiometric detection of methanol in commercial biodiesel with improved sensitivities. Journal of Materials Chemistry C, 2020, 8, 16808-16814.
20. Xunyuan Jiang, Shuai Yang, Yin Yan, Fei Lin, Ling Zhang, Weijing Zhao, Chen Zhao*, Hanhong Xu*. Design, synthesis, and insecticidal activity of 5,5-disubstituted 4,5-dihydropyrazolo[1,5‑a]quinazolines as novel antagonists of GABA receptors. Journal of Agricultural and Food Chemistry 2020, 68, 15005−15014.
21. Shuai Yang, Kaijie Xu, Qiuqin Lai, Chen Zhao,* Hanhong Xu*. Design, synthesis and insecticidal-activity evaluation of N-pyridylpyrazolo-5-methyl amines and its derivatives. Journal of Heterocyclic Chemistry, 2020, 57(12), 4304-4311.
22. Xunyuan Jiang, Xiaoyi Wei, Fei Lin, Zhixiang Zhang, Guangkai Yao, Shuai Yang, Weijing Zhao, Chen Zhao,* Hanhong Xu.* Substrate-controlled [5+1] annulation of 5-amino-1H-phenylpyrazoles with alkenes: divergent synthesis of multi-substituted 4,5-dihydropyrazolo[1,5-]quinazolines. European Journal of Organic Chemistry, 2020, 3997-4003
23. Shijie Zheng, Xiaomin Lin, Hanxing Wu, Chen Zhao,* Hanhong Xu* Synthesis, bioactivities and phloem uptake of dipeptide‑chlorantraniliprole derivatives. BMC Chemistry, 2020, 14, 22.
24. Qiuqin Lai, Shufan Si, Tianyi Qin, Benjie Li, Hanxiang Wu, Bin Liu,* Hanhong Xu,* Chen Zhao.* A novel red-emissive probe for colorimetric and ratiometric detection of hydrazine and its application in plant imaging. Sensors and Actuators B: Chemical, 2020, 307:127640.
25. Xunyuan Jiang, Shuai Yang, Ying Yan, Fei Lin, Ling Zhang, Weijing Zhao, Chen Zhao,* and Hanhong Xu* Design of a new glutamine-fipronil conjugate with α-amino acid function and its uptake by A. thaliana Lysine Histidine Transporter 1 (AtLHT1). J. Agric. Food Chem. 2018, 66, 7597-7605.
26. Qingqing Sheng, Xinxin Liu, Yun Xie, Fei Lin, Zhixiang Zhang, Chen Zhao,* and Hanhong Xu.* Synthesis of novel amino acid-fipronil conjugates and study on their phloem loading mechanism. Molecules 2018, 23, 778.
27. Guangkai Yao, Yingjie Wen, Chen Zhao,* Hanhong Xu.* Novel amino acid ester-chlorantraniliprole conjugates: design, synthesis, phloem accumulation and bioactivity. Pest Management Science 2017, 73, 2131-2137.
28. 杨帅, 江薰垣, 张悦, 赵晨*, 徐汉虹*. 苯基吡唑类化合物的合成、杀虫活性及对蜜蜂的毒性[J]. 学报, 2020, 41(3): 1-8.
29. Chen Zhao, Robert M. Parrish, Mark D. Smith, Perry J. Pellechia, C. David Sherrill, and Ken D. Shimizu.* Do Deuteriums Form Stronger CH-π Interactions? Journal of the American Chemical Society, 2012, 134, 14306-14309.
30. Chen Zhao, Ping Li, Mark D. Smith, Perry J. Pellechia, and Ken D. Shimizu.* Experimental Study of the Cooperativity of CH−π Interactions. Organic Letters, 2014, 16, 3520-3523.
31. Chen Zhao, Bin Liu, Xiaoman Bi, Danqing Liu, Chengjun Pan, Lei Wang,* Yi Pang.* A Novel Flavonoid-Based Bioprobe for Intracellular Recognition of Cu2+ and Its Complex with Cu2+ for Secondary Sensing of Pyrophosphate. Sensors and Actuators B: Chemical, 2016, 229, 131-137.
32. Li, P.; Zhao, C.; Smith, M. D.; Shimizu, K. D. “Comprehensive Experimental Study of N-Heterocyclic π-Stacking Interactions of Neutral and Cationic Pyridines.” The Journal of Organic Chemistry. 2013, 78, 5303-5313.
33. Carroll, W. R.; Zhao, C.; Smith, M. D.; Pellechia, P. J.; Shimizu, K. D. “A Molecular Balance for Measuring Aliphatic CH-π Interactions.” Organic Letters, 2011, 13, 4320-4323.
34. Wang, X.; Fang, F.; Zhao, C.; Tian, S. K. “Dual-Reagent Organocatalysis with a Phosphine and Electron-Deficient Alkene: Application to the Henry Reaction.” Tetrahedron Letters, 2008, 45, 6442-6444.
2. 赵晨，秦天依，徐汉虹. 一种农药荧光标记成像材料及其制备方法和应用. 授权专利号：2021104615471.
3. 徐汉虹，秦天依，赵晨. 一种基于荧光分析的农药-靶标蛋白筛选方法. 授权专利号：ZL2021104615310.
4. 徐汉虹，秦天依，赵晨. 一种基于荧光分析的农药检测方法. 授权专利号：ZL2021104614905.
5. 徐汉虹，江薰垣，赵晨，赖秋勤，邓成菊，张志祥，林菲。一类稠杂环化合物的制备方法. 授权专利号：ZL201910068917.8.
6. 徐汉虹，江薰垣，魏孝义，张志祥，林菲，邓成菊，赵晨，杨帅，赵伟靖。一类含吡唑环的稠合杂环化合物及其应用. 授权专利号：ZL201810219338.4.
7. 徐汉虹，于艾鑫，梁文龙，赵晨，林菲，伍欣宙。一种三唑农药-铜络合物杀菌剂的制备与应用。申请号: CN201710878603.
8. Fused heterocyclic compound, pyrazole-ring-containing fused heterocyclic compound, agricultural composition containing thereof, and method of using the composition. 2019, 美国发明专利,申请号：16/758,053
9. Nitrogen containing fused tricyclic compound and use thereof as agroforestry insecticide. 2019, 欧洲发明专利, 申请号: 18873292.9
10. 一类含吡唑环的稠合杂环化合物及其应用. 2019, 日本发明专利, 申请号: 2020-526237
11. Composto tricíclico fundido contendo nitrogênio eseu uso como inseticida na agrossilvicultura. 2019, 巴西发明专利, 申请号: BR 11 2020 008750 5
《农产品安全检测》、《植物化学保护》、《绿色农药与农业可持续发展》等
研究生课程：
《植物保护政策与法规》、《现代农药研究进展》《植物源杀虫成分及其机理》等
