以下信息为主动公开的研究生招生宣传信息
目录
许小霞   更新日期: 2022年3月2日
许小霞,女,汉族,1977年11月生,安徽黄山市人,中共党员,博士研究生学历,研究员,博、硕导。
工作单位   植物保护学院
邮政编码  510642
通讯地址   资源环境学院539
邮箱地址  xuxiaoxia111@scau.edu.cn
个人简介
许小霞,女,中山大学理学博士毕业,副教授,硕士研究生导师,安徽黄山人。汉族,中共党员。2011年12月留在 资源环境学院/教育部生物防治工程中心从事科研教学工作;2015年院系调整到现农学院,2020年7月院系调整到植物保护学院工作至今。研究方向:害虫生物防治与基因工程和病虫害绿色防控技术
研究兴趣点:
1)植物次生代谢产物的提纯及在农业病虫害防控中的应用;
2)肠道微生物与宿主昆虫(中肠)免疫互作及协同抗病的分子机理;
3)调控昆虫免疫信号传导的非编码RNA及其功能研究;

主持国家自然科学基金2项,广东省自然科学基金2项,广州市民生科技攻关计划项目1项,精准农业体系岗位体系项目1项,博士后基金各1项,广东省科技计划项目1项,有害生物控制与资源利用国家重点实验室访问学者基金3项。第一参加国家自然科学基金,广东省科技创新战略专项基金(重点领域研发计划),国家重点研发计划“双减项目”3项。现已在《Environmental Pollution》,《Journal of Fungi》《Management of Pest Science》,《Frontiers in Immunology》,《International Journal of Biological Macromolecules》,《Frontiers in Physiology》,《Frontiers in Microbiology》,《Developmental and Comparative Immunology》,《New Biotechnology》等国内外杂志上发表相关论文43篇,申请专利20多项,获得审批8个。
工作经历
2007.09 - 2011.12   资源环境学院               博士后
2010.03 - 2011.12   美国密苏里州立大学-堪萨斯分校        博士后
2016.01 - 2017.01   美国密苏里州立大学-堪萨斯分校        访问学者
2008.12- 至今           资源环境学院               副研究员
2011.12 - 2020.07   农学院                        副研究员
2020.07 - 至今         植物保护学院                副研究员
教育经历
1997.06-2001.06  安徽农业大学    学士学位

2001.09-2004.06      硕士学位

2004.09-2007.06  中山大学        博士学位
社会、学会及学术兼职
植物保护协会
研究领域
1)昆虫免疫外界刺激的信号传导机制及抗菌肽表达调控的 RNAi 研究
阐明害虫免疫防御真菌、细菌和病毒的信号传导机制,利用CRISPR-cas9和RNAi技术阻断或减弱害虫免疫系统的信号传导,使害虫更易感染病菌而死亡,力求为害虫的生物防治提供新的理论和方法。
2)非编码RNA对害虫免疫系统的调控机理
  探索调控害虫免疫系统的非编码RNAs(microRNA, LncRNA ,circRNA),利用转基因技术或工程菌的方法调控非编码RNAs的表达,使害虫免疫系统发生紊乱,而不能免疫防御外界致病菌而死亡,从而达到生物防治害虫的目的
科研项目
1.国家自然科学基金,LnRNA竞争miRNA介导小菜蛾多酚氧化酶基因表达的分子机制,32172498, 2022.01-2025.12,58万,主持
2.广东省自然科学基金,2020A1515010300,miR-308-3p靶向PGRP-SA介导小菜蛾抗菌肽表达的分子机制,2020/10-2021/09,10万元,在研,主持
3.广东省省级农业科技创新及推广项目,病虫害综合防控岗位专家, 2019KJ147,2019/05-2023/04,25万元,主持
4.广东省自然科学基金,2018A030313402,基于miRNA-mRNA双重表达解析小菜蛾中肠免疫Bt的动态分子机制,2018/05-2021/04,10万元,在研,主持
5.广东省科技创新战略专项基金(重点领域研发计划),热带亚热带农业微生物种质资源研究与选育(2018B020205003), 2018/05-2021/04,14万元,在研,参加
6.华南及西南水稻化肥农药减施技术集成研究与示范,子课题华南亚热带稻区特色农药化肥减施增效技术集成与示范2018YFD020030606,23万元,在研,参加
7.国家自然科学基金,miR-308-3p靶向PGRP-LB调控小菜蛾抗菌肽表达的分子机制,31972345, 2020.01-2023.12,58万元,第一参加
8.广州市民生科技攻关计划项目,201803020011,高效抑制蔬菜害虫免疫的新型真菌杀虫剂的研发与应用,2018/04-2020/05,100万元,在研,主持
9.广东省科技计划项目,2014A020208106,基于RNAi技术的粘质沙雷氏菌杀虫剂的研制和应用,2015/01-2017/12,20万元,结题,主持
10.国家自然科学基金青年基金项目,30900943,肽聚糖识别蛋白(PGRPs)介导小菜蛾免疫的机理研究,20102/01-2012/12,19万元,结题,主持
11.中国博士后基金,20080430838,小菜蛾肽聚糖识别蛋白功能的RNAi研究,2009/01-2012/12,3万元,结题,主持
12.有害生物控制与资源利用国家重点实验室访问学者基金,2019SKLBC-KF02,基于miRNA-mRNA双重表达解析草地贪夜蛾中肠免疫细菌的动态机制,2019/01-2021/12,10万元,在研,主持
13.有害生物控制与资源利用国家重点实验室访问学者基金,SKLBC13F05,小菜蛾免疫粘质沙雷氏菌侵染的分子机制,2017/01-2019/12,5万元,结题,主持
14.有害生物控制与资源利用国家重点实验室访问学者基金,SKLBC13F02, βGRPs介导小菜蛾免疫的RNAi研究,2013/01-2015/12,2万元,结题,主持
发表论文
1.Junaid Zafar , Yuxin Zhang , Junlin Huang , Shoaib Freed , Rana Fartab Shoukat , Xiaoxia Xu,and Fengliang Jin. Spatio-Temporal Profiling of Metarhizium anisopliae-Responsive microRNAs Involved in Modulation of Plutella xylostella Immunity and Development. J. Fungi 2021, 7, 942.https://doi.org/10.3390/jof7110942.(IF=5.169,Q1)
2.Surajit De Mandal, Amrita Kumari Panda, Chandran Murugan, Xiaoxia Xu, N. Senthil Kumar, and Fengliang Jin*.Antimicrobial Peptides: novel source and biological function with a spatial focus on entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex. Frontiers in microbiology,2021,12:555022.doi:10.3389/fmicb.2021.555022(IF=5.640,Q1)
3.Shuzhong Li, Xiaoxia Xu, Muhammad Shakeel, Surajit De Mandal, Dongran Fu, Fengliang Jin *, Gut microbiota mediate Plutella xylostella susceptibility to Bt Cry1Ac protoxin associated with host immune response, Environmental Pollution,2021(IF=8.071,Q1)
4.Surajit De Manda, Boda Lin, Miaojun Shi, Yapeng Li, Xiaoxia Xu*, FengliangJin*.iTRAQ-Based comparative proteomic analysis of larval midgut from the beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) challenged with  the entomopathogenic bacteria Serratia marcescens. Fontiers in Physiology, 2020 (IF=4.319,Q2)
5.Shuzhong Li, Surajit De Mandal, Xiaoxia Xu and Fengliang Jin *, The Tripartite Interaction of Host Immunity–Bacillus thuringiensis Infection–Gut Microbiota, Toxins, 2020.8. (IF=3.531,Q2)
6.Junaid Zafar, Rana Fartab Shoukat, Yuxin Zhang, Shoaib Freed, Xiaoxia Xu, Fengliang Jin* ,Metarhizium anisopliae challenges immunity and demography of Plutella xylostella. Insects.2020, (IF=2.319,Q2)
7.Rana Fartab Shoukat , Muhammad Shakeel† , Syed Arif, Hussain Rizvi , Junaid Zafar , Yuxin Zhang, Shoaib Freed , Xiaoxia Xu , Fengliang Jin* .Larvicidal, ovicidal, synergistic, and repellent activities of Sophora alopecuroides and its dominant constituents against Aedes albopictus.Insects.2020,11(4). pii: E246. doi: 10.3390/insects11040246.  (IF=2.319,Q2)
8.Rana Fartab Shouka, Junaid Zafar, Muhammad Shakeel, Yuxin Zhang , Shoaib Freed, Xiaoxia Xu, FengliangJin*.Assessment of Lethal, Sublethal, and Transgenerational Effects of Beauveria Bassiana on the Demography of Aedes Albopictus (Culicidae: Diptera).Insects. 2020 ,11(3). pii: E178.(IF=2.319,Q2)
9.Zhantao Zhang, Jinrong Kong, Surajit De Mandal, Shuzhong Li, Zhihua Zheng, FengliangJin*, Xiaoxia Xu*. An immune-responsive PGRP-S1 regulates the expression of antibacterial peptide genes in diamondback moth,Plutella xylostella(L.), International Journal of Biological Macromolecules, 2020, 142:114-124.(IF=5.136,Q2)
10.Chengxing Wang, Fengliang Jin, Surajit De Manda, Lu Zeng, Yuxin Zhang, Yanyan Hua, Yingying Hong, Can Zhao, Junzhai Li, Dunsong Li,Xiaoxia Xu.Insights into the venom protein components of the eggparasitoid Anastatus japonicus (Hymenoptera: Eupelmidae),Pest Management Science,2020 doi: 10.1002/ps.5750. (IF=3.255, Q1)
11.Rana Fartab Shouka, Babar Hassan, Muhammad Shakeel, Junaid Zafar, Shuzhong Li, Shoaib Freed, Xiaoxia Xu, Fengliang Jin*.Pathogenicity and Transgenerational Effects of Metarhizium anisopliae on the Demographic Parameters of Aedes albopictus (Culicidae: Diptera), Journal of Medical Entomology, 2020,57(3):677-685. (IF=1.925, Q1).
12.Xiaoxia Xu, Anqiao Zhong,Yansheng Wang, Boda Lin, Peng Li, Xiaojia Zhu, Jing Yu, Wenyan Ju, Surajit De Mandal,Fengliang Jin*.Molecular identification of a Moricin family antimicrobial peptide (Px-Mor) from Plutella xylostella with activities against the opportunistic human pathogen Aureobasidium pullulans, Frontiers in microbiology,2019,10:2211. (IF=4.2,Q2)
13.Munmun Chowdhury, Jie Zhang, Xiaoxia Xu, Zhen He, Yuzhen Lu, Xusheng Liu,Yufeng Wang, Xiaoqiang Yu. An in vitro study of NF-κB factors cooperatively in regulation of Drosophila melanogaster antimicrobial peptide genes. Developmental and Comparative Immunology. 2019,95:50-58. (IF=2.91,Q3)
14.Surajit De Mandal, Muhammad Shakeel, Vasantha Srinivasan Prabhakaran, Sengodan Karthi, Xiaoxia Xu, Fengliang Jin*. Alternative splicing and insect ryanodine receptor, Arch. Insect Biochem. Physiol. 2019;e21590. (IF= 1.536,Q2)
15.Muhammad Shakeel, Xiaoxia Xu, Surajit De Mandal, Fengliang Jin*.Role of serine protease inhibitors in insect-host-pathogen interactions. Arch. Insect Biochem. Physiol. 2019;e21556. (IF=1.536,Q2)
16.Shuzhong Li, Xiaoxia Xu, Zhihua Zheng, Jinlong Zheng, Muhammad Shakeela, Fengliang Jin*.MicroRNA expression profiling of Plutella xylostella after challenge with Bacillus thuringiensis, Developmental and Comparative Immunology, 2019 93:115-124. (IF=2.9,Q3).
17.Shuzhong Li, Xiaoxia Xu, Muhammad Shakeel, Jin Xu, Zhihua Zheng,  Jinlong Zheng, Xiaoqiang Yu, Qian Zhao, Fengliang Jin*. Bacillus thuringiensis suppresses the humoral immune system to overcome defense mechanism of Plutella xylostella, Fontiers in Physiology,2018,9:1478.(IF=4.2,Q2)
18.Muhammad Shakeel, Xiaoxia Xu, Jin Xu, Shuzhong Li, Xianqiang zhou, Jialin Yu, Xiaojing Xu, Qiongbo Hu, Xiaoqiang Yu, Fengliang Jin*. Genome-wide identification of destruxin A-responsive immunity-related microRNAs in diamondback moth, Plutella xylostella. Frontiers in Immunology, 2018,9:185. (IF=6.428,Q2)
19.Jin Xu, Xiaoxia Xu, Shuzhong Li,Shuang Wang, Xiaojing Xu, Xianqiang zhou, Jialin Yu, Xiaoqiang Yu , Muhammad Shakeel, Fengliang Jin*.Genome-wide profiling of Plutella xylostella immunity-related miRNAs after Isaria fumosorosea infection, Frontiers in physiology, 2017,8:1054. doi: 10.3389/fphys.2017.01054. (IF=4.2,Q2)
20.Jin Xu, Xiaoxia Xu, Muhammad Shakeel, Shuzhong Li,Shuang Wang, Xianqiang zhou, Jialin Yu, Xiaojing Xu, Xiaoqiang Yu,Fengliang Jin*. The entomopathogenic fungi Isaria fumosorosea plays a vital role in suppressing the immune system of Plutella xylostella: RNA-Seq and DGE analysis of immunity-related genes, Frontiers in microbiology, 2017,8:1421. (IF=4.1,Q2)
21.Muhammad Shakeel, Xiaoxia Xu, Jin Xu, Shuzhong Li, Xianqiang zhou, Jialin Yu, Xiaojing Xu, Qiongbo Hu, Xiaoqiang Yu, Fengliang Jin*. Plutella xylostella has the potential to clear the infection of fungal peptide destruxin A: RNA-Seq and DGE analysis of immunity-related genes at genomic level. Scientific Reports, 2017,7(1):10966. (IF=4.28,Q2)
22.Gang Gao, Xiaoxia Xu, Shoaib Freed, Jing Yu, Linmiao Li, Wenyan Ju, Fengliang Jin*,Identification and molecular characterization of two serine proteases and their potential involvement in prophenoloxidase activation in Plutella xylostella, Archives of Insect Biochemistry and Physiology, 2016, 93(1):25-39 . (IF=1.91,Q2)
23.Xiaoxia Xu, Yuqing Zhang, Shoaib Freed, Jing Yu, Yanfu Gao, Shuang Wang, Lina Ouyang, Wenyan Ju and Fengliang Jin*, An anionic defensin from Plutella xylostella with activity against Bacillus thuringiensis , Bulletin of Entomological Research,2016, 106(6):790-800(IF=1.72,Q3)
24.Xiaoxia Xu, Fengliang Jin*, Yangsheng Wang, Shoaib Freed, Qiongbo Hu, Shunxiang Ren.Molecular cloning and characterization of gloverin from the diamondback moth, Plutella xylostella L. and its interaction with bacterial membrane.World Journal of Microbiology and Biotechnology, 2015,31(10):1529-41. (IF=1.66,Q3)
25.Lina Ouyang, Xiaoxia Xu, Shoaib Freed, Yanfu Gao, Jing Yu, Shuang Wang, Wenyan Ju, Yuqing Zhang, Fengliang Jin*, Cecropins from Plutella xylostella and their interaction with Metarhizium anisopliae, Plos ONE, 2015, 10(11):e0142451(IF=3.2,Q2)
26.Wanjun Huang, Xiaoxia Xu, Shoaib Freed, Zhihua Zheng, Shuang Wang, Shunxiang Ren, Fengliang Jin*, Molecular cloning and characterization of a β-1,3-glucan recognition proteins from Plutella xylostella (L.). New Biotechnol., 2015, 32(2): 290-299(IF=3.813,Q3)
27.Qiang Sun, Xiaoxia Xu,Shoaib Freed ,Wanjun Huang,Zhihua Zheng, Shuang Wang, Shunxiang Ren,Fengliang Jin*. Molecular characterization of a short peptidoglycan recognition protein (PGRP-S) from Asian corn borer (Ostrinia furnacalis) and its role in triggering proPO activity, World J Microbiol Biotechnol,  2014, 30(1):263-70 (SCI=1.779,Q2)
28.Xiang Meng, Junjie Hu, Xiaoxia Xu, Zeqing Wang, Qiongbu Hu, Fengliang Jin*, Shunxiang Ren. Toxic Effect of Destruxin A on Abnormal Wing disc-like (SLAWD) in Spodoptera litura Fabricius (Lepidoptera: Noctuidae). PLOS ONE, 2013(28),(SCI=3.2,Q2)
29.Xiaoxia Xu, Xue Zhong, Huiyu Yi ,Xiaoqiang Yu*. Manduca sexta gloverin binds microbial components and is active against bacteria and fungi. Developmental and Comparative Immunology . 38:275-28, 2012( IF=3.268,Q2)
30.Xue Zhong, Xiaoxia Xu, Huiyu Yi, Christopher Lin, Xiaoqiang Yu*. A Toll-Spätzle Pathway in the Tobacco Hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology,42:514-524, 2012. ( IF= 4.018,Q2)
31.XiangJun Rao, Xiaoxia Xu, XiaoQiang Yu*. Functional analysis of two lebocin-related proteins from Manduca sexta. Insect Biochemistry and Molecular Biology,2012, 42: 231-239 ( IF=4.018)
32.Fengliang Jin*, Qiang Sun, Xiaoxia Xu, Linmiao Li, Gang Gao, yingjie Xu, Xiaoqiang Yu, Shunxiang Ren*. cDNA cloning and characterization of the antibacterial peptide cecropin 1 from the diamondback moth, Plutella xylostella L. Protein expression and purification, 85:230-238, 2012. (IF=1.563,Q4)
33.XiangJun Rao, Xiaoxia Xu, Xiao-Qiang Yu*. Manduca sexta moricin promoter elements can increase promoter activities of Drosophila melanogaster antimicrobial peptide genes. Insect Biochemistry and Molecular Biology,2011, 41: 982-992 (IF=4.018,Q2)
34.Xiang Meng,  Xiaoxia Xu , Junjie Hu, Fengliang Jin,Qiongbo Hu,Qiang Sun , Xiaoqiang Yu ,Shunxiang Ren*. Toxicity and differential protein analysis following destruxin A treatment of Spodoptera litura (Lepidoptera: Noctuidae) SL-1 cells . Toxicon, 58: 327–335, 2011 ( IF=2.508,Q3)
35.33.Fengliang Jin ,Xiaoxia Xu ,Xiaoqiang Yu ,Shunxiang Ren .Expression and characterization of antimicrobial peptide CecropinAD in the methylotrophic yeast Pichia pastoris,Process Biochemistry (SCI=2.444,Q3)
36. Fengliang Jin, Xiaoxia Xu, Xiaoqiang Yu ,Shunxiang Ren.High-level expression of active recombinant ubiquitin carboxyl-terminal hydrolase of Drosophila melanogaster in Pichia pastoris.Protein Expr Purif. 2009 65(2):115-21.
37.Fengliang Jin, XiaoLin Dong, Xiaoxia Xu ,Shunxiang Ren. cDNA cloning and recombinant expression of the general odorant binding protein II from Spodoptera litura. Sci China Ser C-Life Sci,2009,51(1) :80-87
38.曹苗苗,鞠雯燕,郑锦龙,张展滔,金丰良,李林妙,许小霞.斜纹夜蛾GNBP1基因的克隆及诱导表达模式的研究[J].环境昆虫学报,2018,40(06):1316-1327.
39.郑锦龙,许小霞,余静,等. 小菜蛾整合素integrin β1 基因的克隆及其功能分析[J]. 环境昆虫学报,2018,40 ( 4) : 880-893.
40.高延富,李俊俊,余静,许小霞. 小菜蛾Cactus 基因的克隆及表达模式研究[J]. 环境昆虫学报,2018,40 ( 1) : 161- 173.
41.余静,许小霞,高延富,金丰良.小菜蛾C 型凝集素基因PxCTL5 的克隆及其在细菌刺激下的转录水平变化.昆虫学报,2017, 60( 8) : 876-890
42.张玉清,许小霞,郑志华,余静,高延富,欧阳莉娜,金丰良.小菜蛾PGRP-SA 的体外表达及介导酚氧化酶活力的研究. 环境昆虫学报,2016,38 ( 3) : 572-581
43.郑志华,许小霞,余静,高延富,张玉清,欧阳莉娜,金丰良.一个调控抗菌肽表达的小菜蛾肽聚糖识别蛋白( PxPGRP-SA). 昆虫学报,2016,59( 5) : 489 -499
44.许小霞,王 爽,张文庆,孙 强,王 超,金丰良.斜纹夜蛾抗菌肽基因Moricin和Cecropin时空表达模式及微生物敏感性的分析.昆虫学报.2012,55( 9) : 1008-1013
45.金丰良,董小林,许小霞,任顺祥.斜纹夜蛾普通气味结合蛋白ⅡcDNA的克隆及在原核细胞中的表达.中国科学 C 辑:生命科学,2008,38(11)1076 ~ 1083
46.金丰良,董小林,许小霞,任顺祥.斜纹夜蛾普通气味结合蛋白ⅠcDNA的克隆及在原核细胞中的表达中国农业科学 2009,42(3):891-899
47.金丰良,张呈文,许小霞,孙强,任顺祥.死亡素与泛素在大肠杆菌中的高效融合表达,昆虫学报.2009, 52( 5 ):495 -501
专著教材
1.Surajit De Mandal, Ajit Kumar Passari, Fengliang Jin, Xiaoxia Xu. Recent Advance and Future Perspectives of Microbial Metabolites, Apllications in Biomedicine.2020
2.Surajit De Mandal, Ajit Kumar Passari, Swati Mahapatra, Fengliang Jin, Xiaoxia Xu. Recent Advance and Future Perspectives of Microbial Metabolites, Apllications in Agriculture.2020
科研创新
申请和授权的专利
1.许小霞,洪莹莹,金丰良,张茂新,凌冰.一种用于刺吸式口器昆虫胃毒的毒力测定装置. 2019.09.24,中国, ZL201921602184.3
2.许小霞,金丰良,洪莹莹,李树忠,林博达,鞠雯燕,曾路,张雨欣,花艳艳,曹苗苗. 一种靶向沉默害虫模式识别蛋白GNBP3基因表达的重组真菌及在害虫防治中的应用,中国, 2019108550746
3.许小霞,张展滔,金丰良,林晓菊,叶凯翔,郑锦龙,孔锦荣,张茂新,凌冰.一种抑制害虫免疫反应的苦瓜素类化合物及其高效制备方法和应用,中国,2019100496480
4.许小霞,金丰良,张展滔, 曾路.一种抑制小菜蛾天然免疫的Serpin7及其编码和应用,中国,202010614504.8
5.许小霞,金丰良,曾路.一类抑制小菜蛾PPO激活的miRNAs,筛选及其应用,中国,202010616495.6
6.许小霞,金丰良,张雨欣.miR-199-x靶向Serpin3调控小菜蛾PO活力及应用,中国,202010614475.5
7.金丰良,许小霞,花艳艳,李树忠.一个活化BtCry1Ac原毒素的Trypsin-9及其应用,中国,202010614484.4
8.金丰良,许小霞,花艳艳,李树忠.一个靶向Trypsin-9调控Bt毒素及营养蛋白活化的miR-283-3p及应用,中国,202010614473.6
9.金丰良,许小霞,高延富,欧阳莉娜,张玉清,余静,鞠雯燕,杨涛,刘长虹,一种抗菌肽PJF11及其在抑制种植体周围炎细菌中的应用. 2015.08.05,中国,ZL201510177255.X
10.金丰良,许小霞,余静,高延富,欧阳莉娜,张玉清,鞠雯燕,杨涛,刘长虹,一种抗菌肽PLC13及其在抑制种植体周围炎细菌中的应用. 2015.08.05,中国, ZL201510177272.3
11.金丰良,许小霞,徐洪芝,一种小菜蛾抗菌肽defensin及其制备方法与应用,2013.09.12,中国,ZL201310411704.3
12.金丰良,许小霞,徐洪芝,一种小菜蛾天蚕素3及其制备方法与应用,2013.09.12,中国,ZL201310411630.3
13.金丰良,许小霞,孙强,黄婉君,一种小菜蛾溶菌酶II及其制备方法与应用,2013.09.12,中国,ZL201310411631.8
14.金丰良,郑志华,许小霞,一种小菜蛾肽聚糖识别蛋白及其制备方法与应用,2013.09.12,中国,ZL201310411690.5
15.金丰良,许小霞,李鹏,一种小菜蛾抗菌肽moricin及其制备方法与应用,2013.09.12,中国,ZL201310411620.X
16.张文庆,金丰良,许小霞,汪延生,陈宏鑫,王娟,一种杂合抗菌肽CA-MA及其重组表达方法,2009.09.12,中国,ZL200910036902.X
17.金丰良,许小霞,洪莹莹,曹苗苗,李树忠,曾路,张雨欣,花艳艳.一种靶向沉默小菜蛾GNBP2基因的重组细菌及在害虫防治中的应用,中国,2019108542665
立项标准
1)增效Bt作用的PxG1肠道菌的鉴定标准
2)高纯度苦瓜素类化合物的制备技术标准
3)靶向抑制害虫酚氧化酶的重组dsRNA   绿僵菌的技术标准
4)靶向抑制害虫天然免疫的重组外源  dsRNA白僵菌的技术标准
5)高效表达外源dsRNA的重组细菌技术标准
6)害虫microRNA的功能验证技术标准
7)昆虫抗菌肽的分离纯化技术标准
8)抗菌肽活性检测方法的技术标准
教学活动
硕士生课程:《分子生物原理与技术》,《基因工程原理与方法》,《小RNA在昆虫学研究中的应用》,《免疫学原理》,《分子免疫学》,《昆虫学研究进展》
本科生课程: 《生物防治》,《分子生物学》,《植物保护专业英语》,《科技文献与论文写作》,《免疫与健康》,《害虫生物防治与基因工程》,《转基因植物与安全性》
指导学生
班主任:2012级,2017级植物保护本科生和2018级硕士研究;
培养本科生:陈麒, 杨婷珺,魏瑶,秦家鲜,林博达,叶凯翔,张伟钊,梦元广
培养研究生:独立培养硕士研究生4届,毕业研究生6名,其中2名学生获得优秀学位论文。
张展滔 2019   PxSerpin-7调控小菜蛾免疫与发育的分子机制 优秀硕士论文
王成兴 2020 结合转录组和蛋白质组深入探索卵寄生蜂-荔枝蝽平腹小蜂的毒液蛋白组分 优秀硕士论文
我的团队
本研究团队依托生物防治教育部工程研究中心和广东省生物农药创制和应用重点实验室。仪器设备精良,科研经费充足。
      本研究团队为昆虫免疫与发育分子实验室,团队成员致力于昆虫免疫和发育的分子机制研究,并力求应用基因工程,RNAi和转基因植物技术开发新型的打破昆虫免疫和发育的,绿色且对人畜安全,环境友好的杀虫剂
       2005年起,一直和美国密苏里(堪萨斯)州立大学生物学院的余小强教授(博士)进行如下合作:1、鳞翅目昆虫免疫和发育相关基因功能的研究;2、昆虫抗菌肽基因的体外改造和表达;3、昆虫抗菌肽基表达调控信号传导机制的RNAi研究。与余小强教授合作已经在国外杂志上发表文章4篇,并有博士研究生的联合培养(美国培养1-2年)。
      2013年开始与加拿大University of Western Ontario(西安大略大学)生物化学系的 Shawn Li 教授进行免疫蛋白磷酸化和糖基化对信号传导的启动机制及免疫蛋白晶体结构解析的研究。
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