目录
先后师从徐汉虹教授与谢素原院士,致力于利用质谱成像技术和其他质谱手段解决当前农药学研究的瓶颈。长期从事农药分析检测新技术研发、昆虫毒理学和动/植物有害生物化学防治研究。利用质谱成像技术和空间分辨多组学技术探究农药对靶标生物的毒理机制和非靶标生物的安全性评价,对新型导向农药在植物中的输导、转移、积累规律进行可视化研究。主持国家自然科学基金、广东省自然科学基金、广州市科技计划项目等9项,近五年以第一或通讯作者(含共同)在《Journal of the American Chemical Society》、《Environmental Science & Technology》、《Science of the Total Environment》和《Journal of Agriculture and Food Chemistry》等化学、农学和环境领域权威期刊发表23篇(IF > 10共3篇,中科院一区TOP共10篇),授权专利4项。承担《植物化学保护》、《农产品安全检测》等课程的教学任务。
2009.09 – 2012.06,广西师范大学,生物化学与分子生物学专业,理学硕士学位
2005.09 – 2009.06,广西师范大学,生物技术专业,理学学士学位
植物保护学院教工优秀党务工作者(2024年)
广东省化工学会理事;
广东省化工学会农药专业委员会秘书;
广东省农业项目专家库入库专家;
广东省科技特派员;
《Chemical Enginerring Journal》、《Journal of Agricultural and Food Chemistry》等SCI杂志审稿人。
2. 基于质谱成像检测技术的植物及昆虫对病虫害的防御、毒理机制研究
3. 新型导向农药分子的设计研发及其时空分布规律的质谱可视化研究
1) 教育部“春晖计划”合作科研项目:基于纳米基材压印质谱成像方法开发及其在药用植物功能性物质的时空可视化研究;2023.5-2025.5;在研;
2) 广东省自然科学基金-青年提升项目:空间分辨多组学技术联合解析手性唑虫酯农药对蜜蜂的立体选择毒理机制;2023.1-2025.12;在研;
3) 广东省自然科学基金-面上项目:基于质谱成像和代谢组学的新烟碱类手性杀虫剂对蜜蜂立体选择毒性差异机制研究;2022.1-2024.12;在研;
4) 国家自然科学基金青年项目:基于质谱成像技术的氯虫苯甲酰胺-丙氨酸乙酯在玉米中时空分布研究;2020.1-2022.12;结题
5) 广东省自然科学基金-面上项目:基于质谱新技术解析氨基酸导向农药在玉米中定向积累及分布规律;2019.10-2022.09;结题;
6) 广州市科技计划项目:基于质谱成像技术的药用植物活性成分时空分布研究;2019.1-2021.12;结题;
7) 广东省普通高校特色创新类项目:基于质谱新技术的导向农药——唑虫酯对蜜蜂代谢通路影响机制研究;2019.5-2021.4;结题;
8) 广东省自然科学基金(博士启动):基于MALDI-TOFMS质谱成像的导向农药时空分布规律研究;2018.5-2021.4;结题;
9) 高层次人才引进启动项目,2017-2022,结题;
1. Qingrong Xie+, Zhen Li+, Yingying Chen, Yuhui Zhao, Yizhu Xu, Zhouyi Hong, Zilong Chen, Zhixiang Zhang, Hanhong Xu*, Zhibin Yin*, Xinzhou Wu*,Mass Spectrometry Imaging Reveals the Morphology-Dependent Toxicological Effects of Nanosilvers on Multiple Organs of Adult Zebrafish (Danio rerio), Environmental Science & Technology, 2024, 58, 10015−10027. (中科院一区,IF=10.8)
2. Lianlian Ma+, Zhibin Yin+, Qingrong Xie, Yizhu Xu, Yingying Chen, Yudi Huang, Zhen Li, Xinhai Zhu, Yuhui Zhao, Wenlin Wen, Hanhong Xu*, Xinzhou Wu*, Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers, Journal of Hazardous Materials, (2023) 131304. (中科院一区,IF=12.2)
3. Dong Chen+, Mingyi Du+, Yudi Huang, Yizhu Xu, Yingying Chen, Lianlian Ma, Qingrong Xie, Xinhai Zhu, Zilong Chen, Hanhong Xu*, Xinzhou Wu*, Zhibin Yin*, Plasmonic polydopamine-modified TiO2 nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging, Nano Research, 2023,16(2): 3028−3039. (中科院二区,IF=9.5)
4. Ping Li +, Yongqing Tian +, Mingyi Du, Qingrong Xie, Yingying Chen, Lianlian Ma, Yudi Huang, Zhibin Yin*, Hanhong Xu*, and Xinzhou Wu*,Mechanism of Rotenone Toxicity against Plutella xylostella: New Perspective from a Spatial Metabolomics and Lipidomics Study,Journal of Agricultural and Food Chemistry, 2023,71,1,211-222. (中科院一区,IF=5.7)
5. Mingyi Du+, Zhibin Yin+, Kaijie Xu, Yudi Huang, Yizhu Xu, Wenlin Wen ,Zhixiang Zhang*, Hanhong Xu*, and Xinzhou Wu*,Integrated mass spectrometry imaging and metabolomics reveals sublethal effects of indoxacarb on the red fire ant Solenopsis invicta, Pest Management Science, 2023, 79,3122-3132.. (中科院一区,IF=3.8)
6. Dong Chen, Yizhu Xu, Yudi Huang, Yingying Chen, Yuhui Zhao, Bin Yan, Xinhai Zhu, Zilong Chen, Hanhong Xu*, Zhibin Yin*, and Xinzhou Wu*,Mapping Molecular Signatures in Plant Leaves, Flowers, and Fruits by a TiO2 Nanotube-Based Plasmonic Chip for Imprint Mass Spectrometry Imaging, ACS Agricultural Science & Technology, 2023,3,119−130.(IF=2.3, 封面文章)
7. Ping Li+, Yingying Chen+, Qingrong Xie, Yizhu Xu, Zhen Li, Yuan Li, Zhibin Yin*, Xinhai Zhu, Hanhong Xu*, and Xinzhou Wu*, Spatiotemporal visualization of the synthesis and accumulation of rotenone in Derris elliptica roots using mass spectrometry imaging, Advanced AgroChem, 2023, 2, 340–348.
8. Lianlian Ma, Qingrong Xie, Mingyi Du, Yudi Huang, Yingying Chen, Dong Chen, Yizhu Xu, Hanhong Xu*, Xinzhou Wu*, Zhibin Yin*. Sample preparation optimization of insects and zebrafish for whole-body mass spectrometry imaging, Analytical and Bioanalytical Chemistry, 2022, 414, 4777–4790. (中科院二区,IF=3.8)
9. Mingyi Du+, Dong Chen+, Yingying Chen, Yudi Huang, Lianlian Ma, Qingrong Xie, Yizhu Xu, Xinhai Zhu, Zilong Chen, Zhibin Yin*, Hanhong Xu*, and Xinzhou Wu*. Plasmonic gold nanoshell-assisted laser desorption/ionization mass spectrometry for small-biomolecule analysis and tissue imaging, ACS Applied Nano Materials, 2022, 5, 9633-9645. (中科院二区,IF=5.3)
10. Yue Zhang+, Dong Chen+, Yizhu Xu, Lianlian Ma, Mingyi Du, Ping Li, Zhibin Yin*, Hanhong Xu*, Xinzhou Wu*. Stereoselective toxicity mechanism of neonicotinoid dinotefuran in honeybees: New perspective from a spatial metabolomics study, Science of the Total Environment, 2022, 809, 151116. (中科院一区,IF=8.2)
11. Yue Zhang+, Dong Chen+, Mingyi Du, Lianlian Ma, Ping Li, Run Qin, Jiaru Yang, Zhibin Yin*, Xinzhou Wu*, Hanhong Xu*. Insights into the degradation and toxicity difference mechanism of neonicotinoid pesticides in honeybees by mass spectrometry imaging, Science of the Total Environment, 2021, 774, 145170. (中科院一区,IF=8.2)
12. Run Qin+, Ping Li+, Mingyi Du, Lianlian Ma, Yudi Huang, Zhibin Yin*, Yue Zhang, Dong Chen, Hanhong Xu*, Xinzhou Wu*. Spatiotemporal visualization of insecticides and fungicides within fruits and vegetables using gold nanoparticle-immersed paper imprinting mass spectrometry imaging, Nanomaterials, 2021, 11, 1327. (中科院三区,IF=4.4)
13. Zhibin Yin, Mingyi Du, Dong Chen, Wenyang Zhang, Wenjie Huang, Xinzhou Wu*, Shijuan Yan *, Rapid structural discrimination of IgG antibodies by multicharge-state collision-induced unfolding, RSC Adv., 2021, 11, 36502. (中科院三区,IF=3.9)
14. Xinzhou Wu+, Run Qin+, Hanxiang Wu, Guangkai Yao, Yue Zhang, Ping Li, Yizhu Xu, Zhixiang Zhang, Zhibin Yin*, Hanhong Xu*. Nanoparticle-immersed paper imprinting mass spectrometry imaging reveals uptake and translocation mechanism of pesticides in plants, Nano Research, 2020, 13, 611-620. (中科院二区,IF=9.5, 封面文章)
15. Xinzhou Wu, Yue Zhang, Run Qin, Ping Li, Yingjie Wen, Zhibin Yin*, Zhixiang Zhang*, Hanhong Xu*.Discrimination of isomeric monosaccharide derivatives using collision-induced fingerprinting coupled to ion mobility mass spectrometry, Talanta, 2020, 224, 121901. (中科院一区,IF=5.6)
16. Xinzhou Wu, Weifeng Li, Pengran Guo; Zhixiang Zhang*, Hanhong Xu*. Rapid trace detection and isomer quantitation of pesticide residues via matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry, Journal of Agricultural and Food Chemistry, 2018, 66, 3966−3974. (中科院一区,IF=5.7, 封面文章)
17. Xinzhou Wu, Yangrong Yao, Miaomiao Chen, Hanrui Tian, Jun Xiao, Yunyan Xu, Minsong Lin, L. Abella, Chengbo Tian, Congli Gao, Qianyan Zhang*, Suyuan Xie*, Rong-bin Huang, Lan-sun Zheng. Formation of curvature subunit of carbon in combustion, Journal of the American Chemical Society, 2016, 138, 9629-9633. (中科院一区,IF=14.4)
18. Xin-zhou Wu, Zhi-jun Song, Han-hong Xu,*; Heng Zhang, Wei-quan Chen, Hua-ying Liu. Chemical constituents of the aerial part of Derris elliptica. Fitoterapia, 2012, 83, 732-736 (中科院 三区,IF=3.204)
19. 殷志斌,黄文洁,伍欣宙*,晏石娟*.空间分辨代谢组学进展和挑战[J].生物技术通报,2021,37(1):11-30.
20. 伍欣宙,吴瀚翔,张志祥*,徐汉虹*,滴灌施药导向控制害虫虚拟仿真教学系统的设计与应用[J].高教学刊,2021,15:105-108.
21. 伍欣宙,张志祥,徐汉虹*,学科前沿进展融入《植物化学保护学》课程交叉式教学探讨[J]. 教育科学,2021,10:384-388.
1. 伍欣宙,殷志斌,徐汉虹,陈东,一种纳米粒子-hPDA-TDNT材料及其制备方法和应用(ZL 202210504350.6)
2. 伍欣宙,殷志斌,徐汉虹,黎萍,一种提高同分异构体化合物鉴别能力的方法(ZL202011231739.5)
3. 殷志斌,伍欣宙,徐汉虹,秦润,一种组织样品快速质谱成像方法(ZL202010079375.7)
4. 谢素原,储小东,王国元,伍欣宙,高聪丽,田寒蕊,童晓明,肖君,张美林,黄荣彬,郑兰荪,一种宏量分离碳氢体系生产富勒烯的方法(ZL 201610384185.X)
《植物化学保护》、《植物保护前沿》、《农药学》、《农产品安全检测》、《植物化学保护教学实习》
参讲研究生课程:
《现代农药研究技术》、《植物源杀虫成分及其机理》、《资源利用与植物保护领域法规案例》