目录
2003年1月至2003年8月：广东中山健邦饲料科技有限公司，任技术服务员；
2011年1月至目前： 动物科学学院，从事动物遗传育种与繁殖专业的教学和科研工作。
2003年9月至2006年6月： ，动物遗传育种与繁殖专业，获硕士学位；
2006年8月至2010年10月：美国夏威夷大学（University of Hawaii），分子生物与生物工程专业，获博士学位；
2、李紫聪（14/20），新型高效“温氏WS501猪配套系”培育与应用，中华人民共和国教育部，高等学校科学研究优秀成果奖（科技进步类），一等奖， 2023.
3、李紫聪（7/10），高效瘦肉型种猪新配套系培育与应用，中国产学研合作促进会，中国产学研合作创新成果奖，一等奖， 2018.
4、李紫聪（2/15），种猪体细胞克隆技术研发与应用，广东省人民政府，广东省科学技术奖（科技进步类），一等奖，2016.
5、李紫聪（19/25），高效瘦肉型种猪及其养殖技术示范推广，中华人民共和国农业部，全国农牧渔业丰收奖，农业技术推广合作奖，2016.
6、李紫聪（2/20），猪克隆技术及优秀克隆种猪应用推广，广东省农业厅，广东省农业技术推广奖，一等奖，2015.
1、2012年入选广东省教育厅高校优秀青年教师人才培养计划
2、2013年入选 青年骨干教师培养计划
3、2014年入选广东省高等学校千百十人才培养工程校级培养计划
4、2019年入选广东省高层次人才特殊支持计划“畜禽种业自主创新团队核心成员”培养计划
2、动物泌乳和母性行为的遗传调控机制；
2、利用piggyBac转座子系统介导的基因转移技术提高精子载体法制备转基因猪效率的研究， 国家自然科学基金青年科学基金项目， 2012年起2014年，总经费22 万元。
3、优质环保转基因猪新品种培育，国家转基因生物新品种培育科技重大专项课题，2016年-2020年，总经费3084万元。
4、高效种猪体细胞克隆扩繁技术研究与应用示范，广东省科技计划项目，2016年-2018年，总经费15万元。
5、猪规模化高效体细胞克隆扩繁技术研发与应用，广东省 科技计划项目，2016年-2019年，总经费300万元。
6、下调组蛋白修饰H3K9me3的水平对猪克隆胚胎基因表达模式及发育效率的影响，国家自然科学基金面上项目，2018年-2021年，总经费66万元。
7、调控猪克隆胚胎发育效率的关键印记基因鉴定及高效猪克隆方法建立，广东省自然科学基金-温氏联合基金项目，2020年-2022年，总经费50万元。
8、畜禽种业自主创新团队子课题，广东特支计划本土创新创业团队项目，2020年-2025年，总经费100万元。
9、高繁大黑猪新品种培育及繁育体系构建，国家重点研发计划项目子课题，2022年-2026年，总经费420万元。
10、瘦肉型猪本土化选育提高及专门化品系培育，广东省乡村振兴战略专项种业振兴项目，2023年-2025年，总经费300万元。
11、猪基因编辑干细胞育种技术研发与新种质创制，生物育种专项项目“优质猪新品种设计与培育”课题， 2023年-2025年，总经费340万元。
12、温氏优质大黑猪新品种的分子辅助选育，广东温氏种猪科技有限公司横向课题，2022年-2024年，总经费80万元。
2. Li Z, Zhang Y, Cao J, Xing X, Liang Y, Zhang Y, Tang X, Lin S, Wu Z, Li Z (Co-corresponding author), Huang S. Supplementation of SkQ1 Increases Mouse In Vitro Oocyte Maturation and Subsequent Embryonic Development by Reducing Oxidative Stress. Pharmaceuticals (Basel). 2024 Apr 2;17(4):455.
3. Wang W, Wang S, Wang H, Zheng E, Wu Z, Li Z (Corresponding author). Protein Dynamic Landscape during Mouse Mammary Gland Development from Virgin to Pregnant, Lactating, and Involuting Stages. J Agric Food Chem. 2024 Apr 3;72(13):7546-7557.
4. Cao J, Dong Y, Li Z, Wang S, Wu Z, Zheng E, Li Z (Corresponding author). Treatment of Donor Cells with Oxidative Phosphorylation Inhibitor CPI Enhances Porcine Cloned Embryo Development. Animals (Basel). 2024 Apr 30;14(9):1362.
5. Hong L, Zang X, Hu Q, He Y, Xu Z, Xie Y, Gu T, Yang H, Yang J, Shi J, Zheng E, Huang S, Xu Z, Liu D, Cai G, Li Z (Co-corresponding author), Wu Z. Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation. Journal of Nanobiotechnology. 2023;21(1):79. 2022 IF=10.20.
6. Zhao H, He X, Zhang X, Shi J, Zhou R, Mai R, Su Q, Cai G, Huang S, Xu Z, Wu Z, Li Z (Corresponding author). Progesterone and Androstenedione Are Important Follicular Fluid Factors Regulating Porcine Oocyte Maturation Quality. Animals (Basel). 2023, 13(11), 1811. 2022 IF=3.231.
7. Xing X, Liang Y, Li Y, Zhao Y, Zhang Y, Li Z, Li Z (Co-corresponding author), Wu Z. Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway. Molecules. 2023;28(14):5533. 2022 IF=4.927.
8. Zhou C, Cheng X, Meng F, Wang Y, Luo W, Zheng E, Cai G, Wu Z, Li Z (Co-corresponding author), Hong L. Identification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs. BMC Genomics. 2023;24(1):412. 2022 IF=4.4.
9. Peng J, Hou Y, Wu S, Li Z (Co-corresponding author), Wu Z. Knockout of Rlim Results in a Sex Ratio Shift toward Males but Superovulation Cannot Compensate for the Reduced Litter Size. Animals (Basel). 2023;13(6):1079. 2022 IF=3.231.
10. Xing X, Peng J, Zhao J, Shi R, Wang C, Zhang Z, Wang Z, Li Z (Co-corresponding author), Wu Z. Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging. Frontiers in Nutrition. 2023;10:1192758. 2022 IF=6.59.
11. Zeng F, Liao S, Kuang Z, Zhu Q, Wei H, Shi J, Zheng E, Xu Z, Huang S, Hong L, Gu T, Yang J, Yang H, Cai G, Moisyadi S, Urschitz J, Li Z (Co-corresponding author), Wu Z. Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor. Cells. 2022;11(15):2378. 2022 IF=7.666.
12. Dong Y, Wu X, Peng X, Yang L, Tan B, Zhao H, Zheng E, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Knockdown of YY1 Inhibits XIST Expression and Enhances Cloned Pig Embryo Development. International Journal of Molecular Science. 2022;23(23):14572. 2022 IF=6.208.
13. Zhang Y, Yang L, Zhang Y, Liang Y, Zhao H, Li Y, Cai G, Wu Z, Li Z (Corresponding author). Identification of Important Factors Causing Developmental Arrest in Cloned Pig Embryos by Embryo Biopsy Combined with Microproteomics. International Journal of Molecular Science. 2022;23(24):15975. 2022 IF=6.208.
14. Zhao H, Dong Y, Zhang Y, Wu X, Zhang X, Liang Y, Li Y, Zeng F, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development. Molecules. 2022;27(20):6830. 2022 IF=4.927.
15. Wang W, Zang X, Liu Y, Liang Y, Cai G, Wu Z, Li Z (Corresponding author). Dynamic miRNA Landscape Links Mammary Gland Development to the Regulation of Milk Protein Expression in Mice. Animals (Basel). 2022;12(6):727. 2022 IF=3.231
16. Tan B, Zeng J, Meng F, Wang S, Xiao L, Zhao X, Hong L, Zheng E, Wu Z, Li Z(Co-corresponding author), Gu T. Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles. BMC Genomics. 2022;23(1):804. 2022 IF=4.4.
17. Zhang X, Zhao H, Li Y, Zhang Y, Liang Y, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Amphiregulin Supplementation During Pig Oocyte In Vitro Maturation Enhances Subsequent Development of Cloned Embryos by Promoting Cumulus Cell Proliferation. Cell Reprogram. 2022;24(4):175-185. 2021 IF=2.257.
18. Yang L, Wu X, Zhang N, Shi J, Zhou R, Su Q, Zheng E, Huang S, Xu Z, Hong L, Gu T, Yang J, Yang H, Cai G, Wu Z, Li Z (Corresponding author). Knockdown of RLIM inhibits XIST expression and improves developmental competence of cloned male pig embryos. Mol Reprod Dev. 2021 Mar;88(3):228-237.
19. Wu X, Zhao H, Lai J, Zhang N, Shi J, Zhou R, Su Q, Zheng E, Xu Z, Huang S, Hong L, Gu T, Yang J, Yang H, Cai G, Wu Z, Li Z (Corresponding author). Interleukin 17D Enhances the Developmental Competence of Cloned Pig Embryos by Inhibiting Apoptosis and Promoting Embryonic Genome Activation. Animals (Basel). 2021 Oct 26;11(11):3062.
20. Ao Z, Wu Z, Zhao H, Wu Z, Li Z (Corresponding author). Associations of cord metabolome and biochemical parameters with the neonatal deaths of cloned pigs. Reprod Domest Anim. 2021 Dec;56(12):1519-1528.
21. Ao Z, Gu T, Zhao H, Shi J, Zheng E, Cai G, Wu Z, Li Z (Corresponding author). The pathophysiological changes associated with neonatal death of cloned pigs. Reproduction. 2020 Aug;160(2):193-203.
22. Zeng F, Zhao C, Wu X, Dong R, Li G, Zhu Q, Zheng E, Liu D, Yang J, Moisyadi S, Urschitz J, Li Z (Corresponding author), Wu Z. Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infection. Scientific Report. 2020 Sep 29;10(1):16020.
23. Huang X, Zou X, Xu Z, Tang F, Shi J, Zheng E, Liu D, Moisyadi S, Urschitz J, Wu Z, Li Z (Corresponding author). Efficient deletion of LoxP-flanked selectable marker genes from the genome of transgenic pigs by an engineered Cre recombinase. Transgenic Res. 2020 Jun;29(3):307-319.
24. Zhao H, Xie S, Zhang N, Ao Z, Wu X, Yang L, Shi J, Mai R, Zheng E, Cai G, Wu Z, Li Z (Corresponding author). Source and Follicular Fluid Treatment During the In Vitro Maturation of Recipient Oocytes Affects the Development of Cloned Pig Embryo. Cellular Reprogramming. 2020 Apr;22(2):71-81
25. Ao Z, Li Z (Co-first author), Wang X, Zhao C, Gan Y, Wu X, Zeng F, Shi J, Gu T, Hong L, Zheng E, Liu D, Xu Z, Wu Z, Cai G. Identification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses. Molecular Reproduction and Development. 2019. 86(3):278-291.
26. Yang X, Wu X, Yang Y, Gu T, Hong L, Zheng E, Xu Z, Zeng F, Shi J, Zhou R, Cai G, Wu Z, Li Z (Corresponding author). Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression. Journal of Reproduction and Development. 2019. 65(6):533-539.
27. Ao Z, Wu X, Zhou J, Gu T, Wang X, Shi J, Zhao C, Cai G, Zheng E, Liu D, Wu Z, Li Z (Corresponding author). Cloned pig fetuses exhibit fatty acid deficiency from impaired placental transport. Molecular Reproduction and Development. 2019. 86(11):1569-1581.
28. Tang F, Yang X, Liu D, Zhang X, Huang X, He X, Shi J, Li Z (Co-corresponding author), Wu Z. Co-expression of fat1 and fat2 in transgenic pigs promotes synthesis of polyunsaturated fatty acids. Transgenic Research. 2019. 28(3-4):369-379 .
29. Wang X, Shi J, Cai G, Zheng E, Liu D, Wu Z, Li Z (Corresponding author). Overexpression of MBD3 Improves Reprogramming of Cloned Pig Embryos. Cellular Reprogramming. 2019. 21(5):221-228
30. Zhang X, Li Z (Co-first author), Yang H, Liu D, Cai G, Li G, Mo J, Wang D, Zhong C, Wang H, Sun Y, Shi J, Zheng E, Meng F, Zhang M, He X, Zhou R, Zhang J, Huang M, Zhang R, Li N, Fan M, Yang J, Wu Z. Novel transgenic pigs with enhanced growth and reduced environmental impact. eLife. 2018, 7: e34286.
31. Li Z (First author), Yue Z, Ao Z, Zhao C, Shi J, Zhao C, Zeng F, Cai G, Zheng E, Yang J, Gu T, Yang H, Hong L, Xu Z, Liu D, Wu Z. Maternal dietary supplementation of arginine increases the ratio of total cloned piglets born to total transferred cloned embryos by improving the pregnancy rate of recipient sows. Animal Reproduction Science. 2018, 196:211-218.
32. Zeng F, Dong R, Zhao C, Liu D, Zheng E, Song C, Wu Z, Li Z (Corresponding author). Constitutive expression of antimicrobial peptide PR-39 in transgenic mice significantly enhances resistance to bacterial infection and promotes growth. Transgenic Research. 2018, 27(5):409-422.
33. Zeng F, Li Z (Co-first author), Zhu Q, Dong R, Zhao C, Li G, Li G, Gao W, Jiang G, Zheng E, Cai G, Moisyadi S, Urschitz J, Yang H, Liu D, Wu Z. Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors. Scientific Reports. 2017, 7:41270.
34. Zheng Ao, Dewu Liu, Chengfa Zhao, Zhimin Yue, Junsong Shi, Rong Zhou, Gengyuan Cai, Enqin Zheng, Zicong Li (Co-corrresponding author), Zhenfang Wu. Birth weight, umbilical and placental traits in relation to neonatal loss in cloned pigs. Placenta. 2017, 57: 94-101.
35. Yang Y, Wu D, Liu D, Shi J, Zhou R, He X, Quan J, Cai G, Zheng E, Wu Z, Li Z (Corresponding author). Mutation of the XIST gene up-regulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos. Molecular Reproduction and Development. 2017, 84(6):525-534.
36. Zeng F, Huang Z, Yuan Y, Shi J, Cai G, Liu D, Wu Z, Li Z (Corresponding author). Effects of RNAi-mediated knockdown of Xist on the developmental efficiency of cloned male porcine embryos. Journal of Reproduction and Development. 2016, 62(6) :591-597.
37. Shi J, Zhou R, Luo L, Mai R, Zeng H, He X, Liu D, Zeng F, Cai G, Ji H, Tang F, Wang Q, Wu Z, Li Z (Corresponding author). Influence of embryo handling and transfer method on pig cloning efficiency. Animal Reproduction Science. 2015. 154: 121-127.
38. Xu W, Li Z (Corresponding author), Ouyang Z, Yu B, Shi J, Liu D, Wu Z. RNA-Seq transcriptome ananlysis of porcine cloned and in vitro fertilized blastocysts. Journal of Integrative Agriculture. 2015. 14(5):60345-7.
39. Zhang X, Li Z (Co-first author), Meng F, Wang D, Liu D, He X, Sun Y, Bai Y, Wu Z. Characterization of dual enzyme resulted from bicistronic expression of two β-glucanases. Journal of Integrative Agriculture. 2015. 14(4):732-740.
40. Li Z (First author), Zeng F, Meng F, Xu Z, Zhang X, Huang X, Tang F, Gao W, Shi J, He X, Liu D, Wang C, Urschitz J, Moisyadi S, Wu Z. Generation of transgenic pigs by cytoplasmic injection of piggyBac transposase based pmGENIE-3 plasmids. Biology of Reproduction. 2014. 90(5):93, 1–10.
41. Wu Z, Xu Z, Zou X, Zeng F, Shi J, Liu D, Urschitz J, Moisyadi S, Li Z (Corresponding author), Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer. Transgenic Research. 2013.22:1107-1118.
42. Li Z (First author), He X, Chen L, Shi J, Zhou R, Xu W, Liu D, Wu Z. Bone marrow mesenchymal stem cells are an attractive donor cell type for production of cloned pigs as well as genetically modified cloned pigs by somatic cell nuclear transfer. Cellular Reprogramming. 2013, 15(5):459-70.
43. Li Z (First author), Shi J, Liu D, Zeng H, Zhou X, Mai R, Zhou R, Zeng S, Luo L, Yu W, Zhang S, Wu Z. Effects of donor fibroblast cell type and transferred cloned embryo number on the efficiency of pig cloning. Cellular Reprogramming. 2013. 15(1):35-42.
44. Li Z (First author), Wu Z, Ren G, Zhao Y, Liu D. Expression patterns of insulin-like growth factor system members and their correlations with growth and carcass traits in Landrace and Lantang pigs during postnatal development. Molecular Biology Reports. 2013. 40(5):3569-76.
45. Xu W, Li Z(Co-first author), Yu B, He X, Shi J, Zhou R, Liu D, Wu Z. Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear Transfer. PLoS ONE。 2013. 8(5): e64705.
46. Wang K, Li Z (Co-first author), Li Y, Zeng J, He C, Yang J, Liu D, Wu Z. Muscle-specific transgenic expression of porcine myostatin propeptide enhances muscle growth in mice. Transgenic Research. 2013. 22(5):1011-9.
47. Li Z (First author), Zeng F, Mitchell A, Kim YS, Wu Z, Yang J. Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone formation. Biochemical and Biophysical Research Communications. 2011; 416: 289-92.
48. Li Z (First author), Kawasumi M, Zhao B, Moisyadi S, Yang J. Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra. Molecular Reproduction and Development. 2010; 77: 990-7.
49. Li Z (First author), Zhao B, Kim YS, Hu CY and Yang J. Administration of a mutated myostatin propeptide to neonatal mice significantly enhances skeletal muscle growth. Molecular Reproduction and Development. 2010; 77: 76-82.
50. Li Z (First author), Cao B, Zhao B, Yang X, Fan MZ, Yang J. Decreased expression of calpain and calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal pigs. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 2009; 152: 498-503.
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本科生课程：《动物育种学》、《生物育种导论》；
研究生课程：《动物遗传育种实验技术》、《高级动物生殖生理学》、《动物繁殖理论与生物技术》
