目录
2020/1-2021/1, 美国耶鲁大学，医学院，客座副教授
2010/10 - 2011/10，美国德州农工大学，兽医生物技术学院，联合培养博士
2. 亮氨酸调控巨胞饮促进母猪胎盘营养摄取的作用及机制 2023.01-2026.12，国家自然科学基金面上项目，项目主持9. 母体氨基酸水平对仔代肌内脂肪沉积的影响及机制(2023YFD1301303-8)，2023.12-2028.11，国家重点研发计划项目子课题，项目主持
3. 妊娠母猪赖氨酸动态营养需要及精准营养供给技术(2021YFD1300401)，2021.12-2026.11，国家重点研发计划项目子课题，项目主持
4. 亮氨酸对母猪乳腺催乳素分泌的调控及分子机制(2021A1515010944)，2021.01.01-2023.12.31，广东省基础与应用基础研究基金项目，项目主持
5. 亮氨酸对母猪乳腺催乳素分泌的影响及作用机制(2021A1515010944)，2021.01.01-2023.12.31，广东省基础与应用基础研究基金项目，项目主持
6. 亮氨酸介导巨胞饮促进胎盘母仔营养传递的分子机制(2023A1515010646)，2023.01.01-2025.12.31，广东省自然科学基金面上项目，项目主持
7. 不同饲料添加剂对保育仔猪生长性能、腹泻率、营养物质消化吸收率、肠道菌群、血液指标以及肠道健康的影响(h20220431)，2022.4-1.2023.4，企业横向课题，项目主持
8. 帝斯曼摄生素对断奶仔猪抗生素替代作用的评估试验(h20210694)，2021.7.20-2022.7.30，企业横向课题，项目主持
9. 几种发酵酶解豆粕的质量评估(h20220883)，2022.9.20-2023.10.19，企业横向课题，项目主持
10. 酵母硒对妊娠期母-仔猪抗氧化能力传递的影响及作用(h20220718)，2022.10.31-2023.7.31，企业横向课题，项目主持
(1) Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice. JaJin Wu †, Xiaoyu Zheng†, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen*. Journal of Advanced Research. 2024 Feb 20:S2090-1232(24)00076-6. (IF=10.7, SCI 1 区)
(2) Restored intestinal integrity, nutrients transporters, energy metabolism, antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling. Chang Cui, Caichi Wu, Jun Wang, Ziwei Ma, Xiaoyu Zheng, Pengwei Zhu, Nuan Wang, Yuhua Zhu, Wutai Guan* and Fang Chen*. J Anim Sci Biotechnol. 2022;13(1):129. (IF=6.9, SCI 1 区)
(3) Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets. Chang Cui, Yulong Wei, Yibo Wang, Wen Ma, Xiaoyu Zheng, Jun Wang, Ziwei Ma, Caichi Wu, Licui Chu, Shihai Zhang, Wutai Guan, Fang Chen*. J Anim Sci Biotechnol. 2024 Jan 19;15(1):4. (IF=6.9, SCI 1 区)
(4) Leucine supplementation during late gestation globally alters placental metabolism and nutrient transport via modulation of the PI3K/AKT/mTOR signaling pathway in sows. Chang Cui, Caichi Wu, Jun Wang, Xiaoyu Zheng, Ziwei Ma, Pengwei Zhu, Wutai Guan, Shihai Zhang* and Fang Chen*. Food Funct. 2022;13(4):2083-2097. (IF=6.4, SCI 1 区)
(5) Maternal supplementation with Artemisia annua L. ameliorates intestinal inflammation via inhibiting the TLR4/NF-κB and MAPK pathways and improves the oxidative stability of offspring. Shihai Zhang, Liang Xiong, Chang Cui, Hao Zhao, Zhezhe Tian, Wutai Guan and Fang Chen*. Food Funct. 22;13(18):9311-9323. (IF=6.4, SCI 1 区)
(6) Plant essential oils combined with organic acids restored LPS-induced leaky intestine via gut microbial modulation in weaned piglets. Xiaoyu Zheng †, Yibo Wang †, Xuemei Zhou, Tanyi Deng, Yueqi Zhao, Zhichao Fu, Yulong Wei, Wen Ma, Shihai Zhang, Wutai Guan, Fang Chen *. Animal Nutrition. (IF=6.3, SCI 1 区)
(7) Heat Stress-Induced Fetal Intrauterine Growth Restriction Is Associated with Elevated LPS Levels Along the Maternal Intestine-Placenta-Fetus Axis in Pregnant Mice. Xiaoyu Zheng, Wen Ma, Yibo Wang, Caichi Wu, Jun Wang, Ziwei Ma, Yulong Wei, Chang Cui, Shihai Zhang, Wutai Guan, Fang Chen*. Journal of Agricultural and Food Chemistry. 2023 Dec 13;71(49):19592-19609. (IF=6.1, SCI 1 区)
(8) Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut-Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy. Jiawen Zhang, Jun Wang, Ziwei Ma, Zhichao Fu, Yueqi Zhao, Xiangfang Zeng, Gang Lin, Shihai Zhang, Wutai Guan, Fang Chen*. Antioxidants (Basel). 2024;13(2):141. (IF=7.0, SCI 2 区)
(9) A Mixture of Formic Acid, Benzoic Acid, and Essential Oils Enhanced Growth Performance via Modulating Nutrient Uptake, Mitochondrion Metabolism, and Immunomodulation in Weaned Piglets. Xinyu Wang, Tanyi Deng, Xuemei Zhou, Licui Chu, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen*. Antioxidants (Basel). 2024 Feb 19;13(2):246. (IF=7.0, SCI 2 区)
(10) Dietary protease supplementation improved growth performance and nutrients digestion via modulating intestine barrier, immunological response and microbiota composition in weaned piglets. Tao Liu, Wen Ma, Jun Wang, Yulong Wei, Yibo Wang, Zheng Luo, Ying Zhang, Xiangfang Zeng, Wutai Guan, Dan Shao*, Fang Chen* Antioxidants (Basel)2024 May 24. (IF=7.0, SCI 2 区)
(11) The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox Status via JNK/ P38 Pathway in Porcine Mammary Epithelial Cells. Caichi Wu, Chang Cui, Xiaoyu Zheng, Jun Wang, Ziwei Ma, Pengwei Zhu, Gang Lin, Shihai Zhang, Wutai Guan, Fang Chen *. Frontiers in Veterinary Science. 2022 Apr 1;9:850935. (IF=3.2, SCI 2 区)
(12) Altered Liver Metabolism, Mitochondrial Function, Oxidative Status, and Inflammatory Response in Intrauterine Growth Restriction Piglets with Different Growth Patterns before Weaning. Jun Wang, Pengwei Zhu, Xiaoyu Zheng, Ziwei Ma, Chang Cui, Caichi Wu, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen *. Metabolites. 2022 Nov 1;12(11):1053. (IF=4.1, SCI 3 区)
(13) Dietary Yucca schidigera Extract Supplementation During Late Gestating and Lactating Sows Improves Animal Performance, Nutrient Digestibility, and Manure Ammonia Emission. Fang Chen, Yantao Lv, Pengwei Zhu, Chang Cui, Caichi Wu, Jun Chen, Shihai Zhang, Wutai Guan*. Front Vet Sci. 2021 Jul 21;8:676324 (IF=3.2, SCI 2 区)
(14) Metabolic Transition of Milk Triacylglycerol Synthesis in Response to Varying Levels of Three 18-Carbon Fatty Acids in Porcine Mammary Epithelial Cells. Yantao Lv, Fang Chen, Shihai Zhang, Jun Chen,Yinzhi Zhang, Min Tian, Wutai Guan*. International journal of molecular sciences. 22(3), 1294. (IF=5.6, SCI 2 区)
(15) Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α. Zhihui Wu, Qihui Li, Siwang Yang, Tenghui Zheng, Jiayuan Shao, Wutai Guan, Fang Chen, Shihai Zhang*. Cell Commun Signal. 2022 Mar 5;20(1):25. (IF=4.1, SCI 2 区)
(16)亮氨酸对猪乳腺上皮细胞营养转运的影响及调控机制. 朱鹏巍,吴采池,崔畅,郑小雨,马梓玮,王俊,陈芳*.动物营养学报. 2022 (03),1895-1907.
(17)功能性氨基酸对母猪胎盘功能影响的研究进展. 唐燕妮,施魁,管武太* & 陈芳*.动物营养学报. 2019 (11),4927-4932.
(18)亮氨酸对猪胎盘滋养层细胞增殖及氨基酸转运的影响. 施魁,唐燕妮,刘炀,管武太,陈芳* & 邓跃林*.中国畜牧杂志. 2019. (02),70-74+93.
2. 近三年其它重要成果
(1) Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation. Ming Tian, Qihui Li, Tenghui Zheng, Shihai Zhang, Fang Chen, Wutai Guan *, & Shihai Zhang*. 2023 Gut microbes. 15(1), 2206505. (IF=12.2, SCI 1区)
(2) Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α. Zhihui Wu, Qihui Li, Siwang Yang, Tenghui Zheng, Jiayuan Shao, Wutai Guan, Fang Chen*, & Shihai Zhang*. Cell communication and signaling. 2022 20(1), 25. (IF=8.4, SCI 1区)
(3) Niacin/β-hydroxybutyrate regulates milk fat and milk protein synthesis via the GPR109A/Gi/mTORC1 pathway. Jiaming Chen, Tongbin Lin, Shuchang Zhang, Xianhuai Yue, Xinghong Liu, Caiqi Wu, Yunyi Liang, Xiangfang Zeng, Wen Ren, Fang Chen, Wutai Guan*, & Shihai Zhang*. Food & function. 202314(6), 2642–2656. (IF=6.4, SCI 1 区)
(4) Maternal supplementation with glycerol monolaurate improves the intestinal health of suckling piglets by inhibiting the NF-κB/MAPK pathways and improving oxidative stability. Hao Zhao, Ming Tian, Liang Xiong, Tongbin Lin, Shuchang Zhang, Xianhuai Yue, Xinghong Liu, Fang Chen, Shihai Zhang*, & Wutai Guan* Food & function. 2023. 14(7), 3290–3303. (IF=6.4, SCI 1 区)
(5) Nutritional strategies to alleviate oxidative stress in sows. Qihui Li, Siwang Yang, Fang Chen, Wutai Guan*, & Shihai Zhang *. Animal Nutrition. 2022. 9, 60–73. (IF=6.3, SCI 1区)
(6) Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance. Qihui Li, Tenghui Zheng, Siwang Yang, Qianzi Zhang, Baofeng Li, Xiangfang Zeng, Yongxing Zhong, Fang Chen, Wutai Guan*, & Shihai Zhang*. Animal nutrition. 2023. 14, 213–224. (IF=6.3, SCI 1 区)
(7) Maternal Selenium-Enriched Yeast Supplementation in Sows Enhances Offspring Growth and Antioxidant Status through the Nrf2/Keap1 Pathway. Liang Xiong, Tongbin Lin, Xianhuai Yue, Shuchang Zhang, Xinghong Liu, Fang Chen, Shihai Zhang*, & Wutai Guan*. Antioxidants (Basel). 2023. 12(12), 2064. (IF=7.0, SCI 2 区)
(8) Novel advances in understanding fatty acid–binding G protein–coupled receptors and their roles in controlling energy balance. Ming Tian, Zhihui Wu, Jinghui Heng, Fang Chen, Wutai Guan* & Shihai Zhang*. Nutrition Reviews. 2022;80(2):187-199. (IF=6.1, SCI 2区)
(9) Dietary Supplementation of Enzymatically Treated Artemisia annua L. Improves Lactation Performance, Alleviates Inflammatory Response of Sows Reared Under Heat Stress, and Promotes Gut Development in Preweaning Offspring. Liang Xiong, Wenfei Zhang, Hao Zhao, Zhezhe Tian, Wen Ren, Fang Chen, Wutai Guan*, & Shihai Zhang*. Frontiers in veterinary science. 2022. 9, 843673. (IF=3.2, SCI 2 区)
(10) Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways. Wenfei Zhang, Liang Xiong, Jiaming Chen, Zhezhe Tian, Jiaxin Liu, Fang Chen, Man Ren, Wutai Guan, Shihai Zhang*. Animals. 2021, 11(6): 0-1528. (IF=3.0, SCI 2 区)
(11) Effects of Dietary Monoglyceride and Diglyceride Supplementation on the Performance, Milk Composition, and Immune Status of Sows During Late Gestation and Lactation. Hanqing Song, Wei Chai, Fei Yang, Man Ren, Fang Chen, Wutai Guan, Zhang, Shihai* Frontiers in Veterinary Science. 2021, 8: 71406. (IF=3.2, SCI 2 区)
