Education & Experience
1993 PhD, University of Adelaide, Australia
1985 MSc, South China Agricultural University (SCAU), China
1982 BSc, SCAU, China
PROFESSIONAL EXPERIENCE
13-present Professor / Director， Integrative Microbiology Research Centre，SCAU
09-12 Research Director, Institute of Molecular and Cell Biology, Singapore
02-08 Associate Professor, Institute of Molecular and Cell Biology, Singapore
98-02 Associate Professor (00-02), Lab Head/Senior Scientist (98-02), Institute of Molecular Agrobiology, Singapore
97-98 Lab Head/Senior Scientist, Plant Biotechnology Centre, Victoria, Australia
93-97 Postdoctoral Fellow, University of Queensland, Australia
85-88 Assistant Lecturer (85-86), Lecturer (87-88), SCAU, China
Awards & Honors
2018 Honorary citizen of Guangzhou
2018 Elected Fellow of Chinese Plant Pathology Society
2017 Elected Fellow of American Microbiology Academy
2005 National Science Award, Singapore
2002 Outstanding Researcher Award, National University of Singapore
2001 Elected Member of Asia-Pacific International Molecular Biotechnology Network
Research Fields
Quorum sensing, biofilm, host-pathogen chemical communication, antibiotic resistance
Selected Publications
Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH (2019) Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. P Natl Acad Sci USA. 116(44): 22331-22340.
Dela Ahator S, Zhang L (2019) Small Is Mighty-Chemical Communication Systems in Pseudomonas Aeruginosa. Annual Review of Microbiology 73: 559-578.
Wang J, Wang J, Zhang LH (2018) Immunological blocking of spermidine-mediated host-pathogen communication provides effective control against Pseudomonas aeruginosa infection. Microbiol Biotech 14 May.
Lee J, Wu J, Deng Y, Wang J, Wang J, Wang LH, Chang C, Dong Y, Williams P, Zhang LH (2013) A cell-cell communication signal integrates quorum sensing and stress response. Nature Chem Biol 9, 339-343. (Featured in Nature Chem Biol 9)
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH (2012). Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric quanosine monophosphate turnover. Proc. Natl. Acad. Sci. USA 109: 15479-15484.
Deng Y, Wu J, Tao F, Zhang LH (2011) Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria. Chem Rev 111, 160-173.
Boon C, Deng YY, Wang LH, He YW, Xu JL, Yang F, Pan SQ, Zhang LH (2008) A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME J. 2: 27-36. (Must read – Faculty of 1000)
Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH (2001) Quenching quorum sensing-dependent bacterial infection by an N-acylhomoserine lactonase. Nature 411, 813-817. (Exceptional Read – Faculty of 1000) (Featured in Nature 2001 vol 411, Nature Biotech 2001 vol 19)