研究领域：

活性小分子的设计合成与作用机制研究，农药学，药物化学。

主要从事①病原-寄主跨界通讯系统抑制剂的设计合成与互作机制研究；②糖化学及含杂环有机分子的设计合成以及生物活性研究；③群体感应抑制剂的设计合成。

学习经历：

2000.9-2004.7    中国农业大学国家化学理科基地班 本科

2004.9-2010.6    中国农业大学理学院应用化学系 硕博连读

2008.6-2008.7    中国科学院研究生院  全国“生物化学与分子生物学”研究生暑期学校

2008.10-2009.9    日本千叶大学     联合培养博士生

工作经历：

2016.8 --  群体微生物研究中心  教授   

2017.12-2018.12  美国斯克利普斯研究所（The Scripps Research Institute）化学系  访问学者

2017.6-2017.8  日本千叶大学  JSPS外籍聘用研究员

2013.9-2016.7  副研究员

2012.4-2013.8  日本千叶大学 JST博士后研究员

2012.8-2012.11   北京大学   访问学者

2010.8-2012.7   日本千叶大学 JSPS外籍特别研究员

社会兼职：

担任《中国化学快报》第三届青年编委会委员；

中国化学会农业化学专业委员会委员；

广东省植物保护学会第九届理事会理事；

广东省微生物学会第十届理事会理事；

中国化学会会员；

广东省化学会会员；

日本糖脂协会会员；

美国植物病理学会会员

荣誉与奖励：

2021年    2020年度广东省百名博士博士后创新人物

2020年    广东省杰出青年基金获得者

2020年    2020年首届江苏省研究生精准植保科研创新实践大赛优秀指导教师

2017年    入选国家留学基金委青年骨干教师出国研修项目

2017年    日本学术振兴会（JSPS）外籍聘用研究员JSPS Invitational Fellowship (Short-term)

2016年    荣获第六届中国侨界贡献（创新团队）奖——微生物群体感应创新团队

2015年    入选 “十佳科研团队——微生物信号与群体感应团队”

2015年    入选广州市“珠江科技新星”

2015年    入选广东省省级“千百十人才培养工程”重点培养对象

2012年    日本科学技术振兴机构（JST）博士后研究员

2010年    日本学术振兴会（JSPS）外籍特别研究员

2009年    中国农业大学校长奖学金

2008年    入选国家建设高水平大学公派研究生项目，国家留学基金委员会

2006年    北京农药学会农药奖学金

2004年    北京农药学会农药奖学金

代表性论文：

1 Ahmed,Wasim; Huang, Zi-Hao; Cui, Zi-Ning* Tang, Ri-Yuan*. Design and synthesis of unique thiazoloisoquinolinium thiolates and derivatives. Chin. Chem. Lett., 2021, 32(10), 3211-3214.

2 Tao-Shun Zhou#, Lulu He#, Jing He, Ao-Qi Du, Jin-Biao Yu, Ya-Sheng Li, Si-Jia Wang, Bin Wei*, Zi-Ning Cui*, Hong Wang*. Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors. Bioorganic Chemistry, 2021, 116, 105306.

3 Li, Ya-Sheng#; Mao, Shen#; Zhao, Dong-Sheng#; Wang, Can-Can; Zu, Dan; Yang, Xi; Zhang, Bo; Liu, Gui-Jun; Wang, Si-Jia; Bao, Xiao-Ze; Ye, Xin-Yi; Wei, Bin; Cui, Zi-Ning*; Chen, Jian-Wei*; Wang, Hong*. Rational Design of Newly Phenyl Thiophene (Pyridine) Derivatives as Chemosensitizer for Front-line Chemotherapy Agents and Overcomes P-glycoprotein Mediated MDR in MCF-7/ADR Cell. Bioorganic Chemistry, 2021, 114, 105075

4 He, Min#; Gu, Jingwen#; Li, Sicheng#; Xiang, Xuwen; Jiang, Shan; Cui, Zi-Ning*. Design, synthesis and fungicidal activities of phenazine-1-carboxamida conjugates of 1,3,4-thia(oxa)diazole. Chin. J. Pestic. Sci., 2021, 23(2), 287-295.

5 Li, Ya-Sheng#; He, Min#; Zhou,Tao-Shun; Wang, Qin; He, Lulu; Wang, Si-Jia; Hu, Bei; Wei, Bin*; Wang, Hong*; Cui, Zi-Ning*. 2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors. Eur. J. Med. Chem., 2021, 216, 113336.

6 Li, Ya-Sheng#; Yang, Xi#; Zhao, Dong-Sheng#; Cai, Yue#; Huang, Zhi; Wu, Rui; Wang, Si-Jia; Liu, Gui-Jun; Wang, Jian; Bao, Xiao-Ze; Ye, Xin-Yi; Wei, Bin; Cui, Zi-Ning*; Wang, Hong*. Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2021, 216, 113322.

7 Fan, Zhoulong; Zhao, Shuai; Liu, Tao; Shen, Peng-Xiang; Cui, Zi-Ning; Zhuang, Zhe; Shao, Qian; Chen, Jason S.; Ratnayake, Anokha S.; Flanagan, Mark E.; Kolmel, Dominik K.; Piotrowski, David W.; Richardson, Paul; Yu, Jin-Quan. Merging C(sp3)-H activation with DNA-encoding, Chemical Science, 2020, 11(45), 12282-12288

8 Yinuo Lin#, Wasim Ahmed#, Min He#, Xuwen Xiang, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivity of Phenyl Substituted Furan and Oxazole Carboxylic Acid Derivatives as Potential PDE4 Inhibitors. Eur. J. Med. Chem., 2020, 207, 112795.

9 Tao-Shun Zhou#, Bin Wei#, Min He#, Ya-Sheng Li, Ya-Kun Wang, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Zi-Ning Cui*, Hong Wang*. Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships. J. Enzyme Inhib. Med. Chem., 2020, 35(1),1736-1742

10 Liao, Yixian; Ye, Yilu; Li, Sumei; Zhuang, Yilian; Chen, Liye; Chen, Jianxin; Cui, Zi-Ning; Huo, Lijian; Liu, Shuwen; Song, Gaopeng. Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease. Eur. J. Med. Chem., 2020, 189, 112048.

11 Gao, Yong-Chao; Huang, Zi-Hao; Zhang, Zhao-Sheng; Xie, Jin-Xin; Cui, Zi-Ning*; Tang, Ri-Yuan*. Sulfite-Promoted C-H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur. Synthesis, 2020, 52(17), 2541-2550.

12 Jia-Hao Chen, Wasim Ahmed, Minghua Li, Zhao-Dong Li, Zi-Ning Cui*, Ri-Yuan Tang*. TEMPO Mediated Synthesis of N-Fluoroalkyl Imidazolones by the Reaction of Imidazoles with Iodofluoroacetate. Adv. Synth. Catal., 2020, 362(1), 269-276.

13 Shan Jiang#, Min He#, Xu-Wen Xiang, Muhammad Adnan, Zi-Ning Cui*. Novel S-thiazol-2-yl-furan-2-carbothioate derivatives as potential T3SS inhibitors against Xanthomonas oryzae on rice. J. Agric. Food Chem., 2019, 67(43), 11867-11876.

14 Yixian Liao#, Xiuhua Jia#, Yongmei Tang, Sumei Li, Yipeng Zang, Lei Wang, Yongfeng Gao, Lijian Huo, Zi-Ning Cui*, Gaopeng Song*. Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: structure-based drug design and fragment identification. Bioorg. Med. Chem. Lett., 2019, 29(22), 126720

15 Hui Tao#, Hao Tian#, Shan Jiang#, Xuwen Xiang, Yinuo Lin, Wasim Ahmed, Riyuan Tang*, Zi-Ning Cui*. Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae. Pestic. Biochem. Physiol., 2019, 160, 87-94.

16 Wasim Ahmed#, Xiaojing Yan#, Dekun Hu#, Muhammad Adnan, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivities of Novel Pyrazole Derivatives Containing 5-Phenyl-2-Furan. Bioorg. Med. Chem., 2019, 27(19), 115048.

17 Jian-Chao Deng, Jun-Rong Zhang, Jie-Cheng Huang, Zhi-Sheng Lai, Xin-Yu Tong, Zi-Ning Cui*, Riyuan Tang*. Direct Thiocarbamation of Imidazoheterocycles with Sulfur and Formamides via Dual C-H Sulfurization. Organic & Biomolecular Chemistry, 2019, 17, 7854-7857. 

18 Shan Jiang#, Hui Li#, Wasim Ahmed#, Xuwen Xiang, Gaopeng Song*, Zi-Ning Cui*. Discovery of ethyl 2-nitro-3-arylacrylates molecules as T3SS inhibitor reducing the virulence of plant pathogenic bacteria Xanthomonas. Frontiers in Microbiology, 2019, 10, 1874.

19 Hui Tao#, Hao Tian#, Shan Jiang#, Xuwen Xiang, Wasim Ahmed, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivity of 1,3-Thiazolidine-2-thione Derivatives against Type III Secretion System of Xanthomonas oryzae. Bioorg. Med. Chem., 2019, 27(15), 3364-3371.

20 Hui Tao#, Su-Su Fan#, Shan Jiang, Xuwen Xiang, Xiaojing Yan, Lian-Hui Zhang, Zi-Ning Cui*. Small molecule inhibitors specifically targeting type III secretion system of Xanthomonas oryzae on rice. Int. J. Mol. Sci., 2019, 20, 971

21 Ya-Sheng Li#, Xing-Yu Liu#, Dong-Sheng Zhao#, Yi-Xian Liao, Lian-Hui Zhang, Feng-Zhi Zhang, Gao-Peng Song*, Zi-Ning Cui*. Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors. Bioorg. Med. Chem. Lett., 2018, 28(19), 3271-3275

22 De-Kun Hu#, Dong-Sheng Zhao#, Min He, Hong-Wei Jin, Yong-Mei Tang, Lian-Hui Zhang, Gao-Peng Song*,Zi-Ning Cui*. Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors. Bioorg. Med. Chem. Lett., 2018, 28(19), 3276-3280

23 Xuwen Xiang#, Hui Tao#, Shan Jian, Lian-Hui Zhang, Zi-Ning Cui*. Synthesis and Bioactivity of Thiazolidin-2-cyanamide Derivatives against Type III Secretion System of Xanthomonas oryzae on Rice. Pestic. Biochem. Physiol., 2018, 149, 89-97

24 Ya-Sheng Li #, Dong-Sheng Zhao #, Xing-Yu Liu, Yi-Xian Liao, Hong-Wei Jin, Gao-Peng Song*, Zi-Ning Cui*. Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2018, 151, 546-556

25 Nan Cai, Caixiu Liu, Zhihui Feng, Xinghai Li*, Zhiqiu Qi, Mingshan Ji, Peiwen Qin, Wasim Ahmed, Zi-Ning Cui*. Design, synthesis and SAR of novel 2-glycinamide cyclohexyl sulfonamide derivatives against Botrytis cinerea. Molecules, 2018, 23,740

26 Gaopeng Song#, Sumei Li#, Dekun Hu#, Dongsheng Zhao, Junhua Li, Xiaojun Zheng, Yiming Guo, Xingyu Liu, Lian-Hui Zhang, Zi-Ning Cui*. Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg. Med. Chem., 2017, 25 (20), 5709-5717.

27 Xiang, Xuwen; Liu, Xingyu; Tao, Hui; Cui, Zi-Ning*; Zhang, Lian-Hui. Research progress of c-di-GMP inhibitors, Chin. J. Biotech., 2017, 33(9): 1466−1477

28 Liu, Xingyu; Xiang, Xuwen; Tao, Hui; Cui, Zi-Ning*; Zhang, Lian-Hui. Chemical agents that modulate bacterial biofilm formation and development, Chin. J. Biotech., 2017, 33(9): 1433−1465

29 Wang, Minlong #; Rui, Peng#; Liu, Caixiu; Du, Ying; Qin, Peiwen; Qi, Zhiqiu; Ji, Mingshan; Li, Xinghai*; Cui, Zi-Ning*. Design, synthesis and fungicidal activity of 2-substituted phenyl-2-oxo, 2-hydroxyl and 2-acyloxy ethylsulfonamides, Molecules, 2017, 22(5), 738.

30 Li, Ya-Sheng#; Hu, De-Kun#; Zhao, Dong-Sheng#; Liu, Xing-Yu; Jin, Hong-Wei; Song, Gao-Peng*; Cui, Zi-Ning*; Zhang, Lian-Hui. Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Oxazole Derivatives as Potential PDE4 Inhibitors. Bioorg. Med. Chem., 2017, 25(6), 1852-1859.

31 Liu, Chun-Hui; Chen, Xiao-Yuan; Qin, Pei-Wen; Qi, Zhi-Qiu; Ji, Ming-Shan; Liu, Xing-Yu; Babu, P. Vijaya; Li, Xing-Hai*; Cui, Zi-Ning*. Synthesis, Fungicidal Activity, and Structure Activity Relationship of β-Acylaminocycloalkylsulfonamides against Botrytis cinerea, Sci. Rep., 2017, 7, 42096.

32 Liu, Caixiu#; Yan, Xiaojing#; Wang, Minlong; Qin, Peiwen; Qi, Zhiqiu; Ji, Mingshan; Liu, Xingyu; Babu, P. Vijaya; Li, Xinghai*; Cui, Zi-Ning*. Design, synthesis and fungicidal activity of novel 2-substituted aminocycloalkylsulfonamides. Bioorg. Med. Chem. Lett., 2017, 27(2), 271-276.

33 Fan, Susu; Tian, Fang*; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Cui, Zi-Ning; Yang, Ching-Hong*; He, Chenyang. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol., 2017, 18(4), 555-568.

34 Zhou, Jia-Nuan#; Zhang, Hai-Bao#; Lv, Ming-Fa; Chen, Yu-Fan; Liao, Li-Sheng; Cheng, Ying-Ying; Liu, Shi-Yin; Chen, Shao-Hua; He, Fei; Cui, Zi-Ning; Jiang, Zi-De; Chang, Changqing*; Zhang, Lian-Hui*. SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol. Plant Pathol., 2016, 17(9), 1398-1408.

35 Wang, Chao; Liu, Xiaoling; Wang, Jing; Zhou, Jianuan; Cui, Zi-Ning; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system in Pseudomonas aeruginosa. Sci. Rep., 2016, 6, 30949.

36 Song, Gaopeng#; Li, Sumei#; Lei, Zhiwei; Li, Yibin; Li, Junhua; Liao, Yixian; Cui, Zi-Ning*. Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity. Org. Biomol. Chem., 2016, 14(28), 6691-6702（cover paper）.

37 Li, Ya-Sheng#; Tian, Hao#; Zhao, Dongsheng#; Hu, De-Kun; Jin Hongwei; Song, Gaopeng*; Cui, Zi-Ning*. Synthesis and Bioactivity of Pyrazole and Triazole Derivatives as Potential PDE4 Inhibitors. Bioorg. Med. Chem. Lett., 2016, 26(15), 3632-3635.

38 Wang, Chao; Liu, Xiaoling; Wang, Jing; Cui, Zining; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system in Pseudomonas aeruginosa. Sci. Rep., 2016, 6, 30949.

39 Fan, Susu; Tian, Fang; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Yang, Cui Zi-Ning, Ching-Hong Yang*; He, Chenyang. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol., 2016, 17(9), 1398-1408.

40 Liu, Chunhui; Cui, Zi-Ning*; Yan, Xiaojing; Qi, Zhiqiu; Ji,Mingshan; Li, Xinghai*. Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2- aminopyrimidines against Botrytis cinerea. Molecules, 2016, 21(7), 828.

41 Song, Gao-Peng #; Hu, De-Kun #; Tian, Hao#; Li, Ya-Sheng; Cao, Yun-Shen; Jin, Hong-Wei*; Cui, Zi-Ning*. Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives. Sci. Rep., 2016, 6, 22977.

42 Song, Gaopeng#; Li, Jianzuo#; Tian, Hao; Li, Yasheng; Hu, Dekun; Li, Ying*; Cui, Zi-Ning*. Synthesis and Antitumor Activity of Novel N-Benzoyl-N'-substituted Pyrimidinyl (Thio)semicarbazide Derivatives. Lett. Drug Des. Discov., 2016, 13(4), 329-334.

43 Cui, Zi-Ning*; Li, Ya-Sheng; Hu, De-Kun; Tian, Hao; Jiang, Jia-Zhen; Wang, Yuan; Yan, Xiao-Jing*. Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan, Sci. Rep., 2016, 6, 20204.

44 Song, Gaopeng; Zhao, Dongsheng; Hu, Dekun; Li, Yasheng; Jin, Hongwei; Cui, Zi-Ning*. Design, Synthesis and Biological Evaluation of NovelTetrahydroisoquinoline Derivatives as Potential PDE4 Inhibitors, Bioorg. Med. Chem. Lett., 2015, 25(20), 4610-4614.

45 Song, Gao-peng; Li, Su-mei; Si, Hong-zong; Li, Yi-bin; Li, Ya-sheng; Fan, Ji-hong; Liang, Qian-qian; He, Hui-bing; Ye, Han-ming; Cui, Zi-Ning*. Synthesis and Bioactivity of Novel Xanthone and Thioxanthone L-Rhamnopyranosides, RSC Adv., 2015, 5(45), 36092-36103.

46 Li, Chengkun; Jiang, Lin; Wang, Yue; Wan, Fuxian; Zhang, Peizhi; Li, Ying; Cui, Zi-Ning*. Design, Synthesis and Biological Activities of N-(Substituted benzoyl)-N′-(5-methoxyl-2- methylsulfanylpyrimidin-4-amino) (thio) Ureas, Chin. J. Org. Chem., 2014, 34(11), 2296-2303.

47 Cui, Zining*; Ito, Jun; Dohi, Hirofumi; Amemiya, Yoshimiki; Nishida, Yoshihiro. Molecular Design and Synthesis of Novel Salicyl Glycoconjugates as Elicitors against Plant Diseases, PLOS One, 2014, 9(9), e108338.

48 Cui, Zining*; Li, Xinghai; Tian, Fang; Yan, Xiaojing. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain, Int. J. Mol. Sci., 2014, 15(5), 8941-8958.

49 Cui, Zining*; Su, Hang; Jiang, Jiazhen; Yang, Xinling; Nishida, Yoshihiro. Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives, Int. J. Mol. Sci., 2014, 15(4), 6741-6756

50 Cui, Zining*; Liang, Zhibin; Tian, Fang; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (I), Chin. J. Pestic. Sci., 2014, 16(3), 252-258.

51 Cui, Zining*; Tian, Fang; Liang, Zhibin; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (II), Chin. J. Pestic. Sci., 2014, 16(4), 394-399.

52 Cui, Zining*; Li, Xing-Hai; Nishida, Yoshihiro. Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan, Lett. Drug Des. Discov., 2014, 11(7), 877-885.

53 Li, Xing-Hai*; Pan, Qiang; Cui, Zi-Ning*; Ji, Ming-Shan; Qi, Zhi-Qiu. Synthesis and Fungicidal Activity of N-(2,4,5-trichlorophenyl)-2-Oxo- and 2-Hydroxycycloalkylsulfon amides, Lett. Drug Des. Discov., 2013, 10(4), 353-359.

54 Li, Xing-Hai#; Cui, Zi-Ning# (first co-author); Chen, Xiao-Yuan; Wu, De-Cai; Qi, Zhi-Qiu; Ji, Ming-Shan*. Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity, Int. J. Mol. Sci., 2013, 14(11), 22544-22557.

55 Cui, Zi-Ning; Shi, Yan-Xia; Zhang, Li; Ling, Yun; Li, Bao-Ju; Nishida, Yoshihiro; Yang, Xin-Ling*. Synthesis and Fungicidal Activity of Novel 2, 5-Disubstituted-1, 3, 4-oxadiazole Derivatives, J. Agric. Food Chem., 2012, 60(47), 11649−11656.

56 Cui, Zi-Ning; Shi, Yan-Xia; Cui, Jing-Rong; Ling, Yun; Li, Bao-Ju; Yang, Xin-Ling*. Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Chem. Biol. Drug Des., 2012, 79(1), 121-127.

57 Cui, Zi-Ning; Yang, Xin-Ling; Shi, Yan-Xia; Uzawa, Hirotaka; Cui, Jing-Rong; Dohi, Hirofumi; Nishida, Yoshihiro*. Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety. Bioorg. Med. Chem. Lett., 2011, 21(23), 7193-7196.

58 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Yang, Xin-Ling; Ling, Yun*. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing Furan（III）. Chin. J. Chem., 2010, 28(7), 1257-1266.

59 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Ling, Yun; Yang, Xin-Ling*. Synthesis, Insecticidal Activity and 3D-QSAR Studies on Diacylhydrazine Derivatives Containing Furan. Chin. J. Org. Chem., 2010, 30(10), 1482-1491.

60 Cui, Zi-Ning; Ling, Yun; Li, Bao-Ju; Li, Yong-Qiang; Rui, Chang-Hui; Cui, Jing-Rong; Shi, Yan-Xia; Yang, Xin-Ling*. Synthesis and Bioactivity of N-benzoyl-N'-[5-(2'- substituted phenyl)-2-furoyl] semicarbazide Derivatives. Molecules, 2010, 15(6), 4267-4282.

61 Cui, Zi-Ning; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jing-Rong; Wang, Rui-Qing; Yang, Xin-Ling*. New Class of Potent Antitumor Acylhydrazone Derivatives Containing Furan. Eur. J. Med. Chem., 2010, 45(12), 5576-5584.

62 Cui, Zi-Ning; Ma, Yong-Qiang; Ling, Yun; Yang, Xin-Ling*. Crystal Structure of Hexa-2-chloro-4-oxo- tetrakis [(1, 4-dioxane-O4) copper(II)]. Analytical Sciences-X-ray Structure Analysis Online, 2009, 25(7), 79-80.

63 Cui, Zi-Ning; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*; Chen, Fu-Heng. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing Furan（I）. Chin. J. Chem., 2008, 26(5), 916-922.

64 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*. 3D-QSAR Studies on Diacylurea Derivatives Containing Furan Moiety. Acta Chim. Sinica, 2008, 66(12), 1417-1423.

65 Cui, Zi-Ning; Wang, Zhen; Li, Ying; Zhou, Xin-Yu; Ling, Yun; Yang, Xin-Ling*. Synthesis and Insecticidal Activity of Diacylhydrazine Containing Furan. Chin. J. Org. Chem., 2007, 27(10):1300-1304.

66 Cui, Zi-Ning; Yang, Lin; Li, Xi-Chen; Wang, Zhen; Yang, Xin-Ling*. Progress in the Study on the Synthesis and the Activities as Insect Growth Regulators of 2, 5-Disubstituted 1, 3, 4- Oxadiazoles. Chin. J. Org. Chem., 2006, 26(12), 1647-1656.

科研创新：

1. 崔紫宁，李司丞，高冬倪，古景文，贺露露。苯并噻唑化合物作为群体感应抑制剂在治疗细菌病害中的应用。申请号：ZL 202010776506.7, 2022-2-22

2. 崔紫宁，邵将，贺露露，古景文，高冬倪。肉桂酸甲酯作为群体感应抑制剂及其在治疗细菌病害中的应用。ZL 202010776777.2, 2022-1-25

3. 崔紫宁，何敏，姜珊，李宇豪，陈恺宏，向绪稳。(S)-1,3-噻唑苯基呋喃硫代甲酸酯类化合物的制备方法和应用。ZL 201910507402.3, 2022-1-25

4. 崔紫宁，姜珊，宋高鹏，李辉，向绪稳。β-硝基丙烯酸乙酯类化合物在预防和/或治疗植物病害中的应用。ZL 201811435644.8，2021-12-24

5. 崔紫宁，王鸿，何敏，魏斌，李亚胜。1,3,4-噻二唑苯基呋喃硫代甲酸酯类化合物在制备α-葡萄糖苷酶抑制剂中的应用。ZL 202011567038.9，2021-9-14

6. 崔紫宁，陶辉，田浩，姜珊，向绪稳。一类取代苯基呋喃-2-巯基噻唑啉甲酮类化合物及其制备方法和应用。ZL 201810954503.0，2021-8-3

7. 崔紫宁，陶辉，向绪稳，姜珊，艾哈迈德•瓦西姆。2-甲氧基苯丙酸化合物在预防和/或治疗植物病害中的应用。ZL 201811435576.5，2021-8-3

8. 崔紫宁，何敏，姜珊，李宇豪，向绪稳。一种含1,2,3,4-四氮唑的呋喃硫代甲酸酯类化合物的制备方法和应用。ZL 201910473201.6，2021-8-3

9. 王鸿，崔紫宁，魏斌，周涛顺。氰基亚胺噻唑烷呋喃甲酰胺类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用。ZL 202010405503.2，2021-7-27

10. 崔紫宁，胡德坤，宋高鹏，向绪稳，陶辉，刘星宇。一种取代苯基呋喃甲酰基吡唑类化合物及其制备方法和应用。ZL 201711042900.2，2021-7-9

11. 崔紫宁，向绪稳，何敏，吴伟生。一种1,3,4-噻(噁)二唑-吩嗪甲酰胺类化合物的制备方法和应用。ZL 201711085061.2，2021-5-28

12. 崔紫宁，艾哈迈德•瓦西姆，向绪稳，宋高鹏，林以诺，李司丞。一种含噁唑环的2-氰基亚氨基噻唑烷类化合物及其制备方法和应用。ZL 201811378136.0, 2021-5-4

13. 崔紫宁，向绪稳，陶辉，姜珊，林以诺。苯丙烯酸化合物在预防和/或治疗植物病害中的应用。申请号：ZL 201811435565.7, 2021-3-30

14. 崔紫宁，向绪稳，陶辉，姜珊，张炼辉。一种氰基亚胺噻唑烷呋喃甲酰胺类化合物及其制备方法和应用。ZL 201710846135.3, 2020-12-29

15. 崔紫宁，陶辉，田浩，向绪稳，姜珊，张炼辉。1,3,4-噻二唑类化合物在防治水稻白叶枯病中的应用。中国发明专利, ZL 201710845900.X, 2020-10-23（已转让）

16. 崔紫宁，李亚胜，胡德坤，田浩，刘星宇，宋高鹏。一种含噁唑环2,4-二取代吡唑类化合物及其制备方法和应用。中国发明专利, ZL 201610885307.3, 2019-10-29

17. 崔紫宁，胡德坤，田浩，李亚胜，宋高鹏，刘星宇。N’-5-（取代苯基)-2-呋喃甲酰基-5-丙基-1H-吡唑-3-甲酸乙酯类化合物及其制备方法与应用。中国发明专利, ZL 201610383248.X, 2018-8-7。

18. 崔紫宁，田浩，胡德坤，李亚胜，宋高鹏，刘星宇。S-(5-取代-1,3,4-噻二唑)-(5-取代苯基)-2-呋喃硫代甲酸酯类化合物及其制备方法与应用。中国发明专利, ZL 201610382784.8, 2018-6-19（已转让）。

19. 宋高鹏，崔紫宁，李俊骅，韦著文，刘星宇。一种含四氢异喹啉并氨基甲酸酯类化合物及其制备方法和应用。中国发明专利, ZL 201610885217.4, 2018-6-19

20. 崔紫宁，陈昱帆，程莹莹，周佳暖，刘诗胤，陈少华。含呋喃环2,5-二取代-1,3,4-噻二唑类化合物在制备致病疫霉菌抑菌剂中的应用，中国发明专利。ZL 201310631983.4, 2016-3-30

21. 崔紫宁，程莹莹，刘诗胤，陈昱帆，周佳暖，陈少华。一种含呋喃环2, 5-二取代-1, 3, 4-噻二唑类化合物及其制备方法和应用，中国发明专利。ZL 201310629477.1, 2015-10-28

22. 崔紫宁，周佳暖，刘诗胤，程莹莹，陈少华。一种苯基取代噻吩甲酰肼类化合物及其制备方法和应用，中国发明专利。ZL 201310574554.8, 2015-06-17

代表性科研项目：

在研项目：

1. 国家自然科学基金（32072450）：水稻白叶枯病菌III型分泌系统抑制剂作用靶标的发现与互作机制的研究。2021年1月-2024年12月，项目主持人。

2. 广东省杰出青年基金（2021B1515020107）：植物病原-寄主跨界通讯系统抑制剂的创制及作用机制研究。2021年1月-2024年12月，项目主持人。

3. 旱区作物逆境生物学国家重点实验室开放课题（CSBAAKF2021009）：稻黄单胞菌T3SS抑制剂作用靶标的发现与互作机制初探。2021年1月-2022年12月，项目主持人。

4. 广东省国际科技合作专题（2020A0505100048）：病原细菌III型分泌系统抑制剂的筛选及病害防控研究。2020年9月-2022年12月，项目主持人。

5. 佛山海关综合技术中心：跨境邮寄物携带水果检疫性细菌病害的危害及药剂防控措施的筛选。2020年11月-2022年10月，项目主持人。

6. 广东省重点领域研发计划项目（2020B0202090001）：基于代谢组学的水稻病虫抗性与产量平衡机制研究。2020年9月-2023年8月，参与。

7. 教育部产学合作协同育人项目（202102195005）：后疫情时代南药主要病虫害产学合作研究与示范。2021年9月-2023年8月，参与。

8. 广东省自然科学基金面上项目（2022A1515010944），根际真菌Albifimbria sp. Cesf-25中农用抗生素的发掘及其作用机制研究。2022年1月-2023年12月，参与。

已结题项目：

1. 国家自然科学基金（31570122）：病原细菌多胺信号转导系统抑制剂的设计与合成。2016年1月-2019年12月，项目主持人。

2. 国家自然科学基金（21102173）：糖基修饰水杨酸衍生物的合成及其抗病诱导活性研究。2012年1月-2014年12月，项目主持人。

3. 国家重点基础研究发展计划——973计划（2015CB150600）：微生物群体感应通讯系统与病害防控基础研究。2015年1月-2019年12月，骨干成员（项目秘书、首席助理、子课题主持）。

4. 国家重点研发计划(2017YFD0200500)：农业生物药物分子靶标发现与绿色药物分子设计。2017年7月-2021年6月，骨干成员（子课题主持）。

5. 广东省公益研究与能力建设专项（2014A020210019）：以拓扑异构酶II为靶点的新型氧杂蒽酮糖基缀合物的合成及构效关系研究。2015年1月-2017年12月，项目主持人。

6. 广东省普通高校特色创新项目(自然科学)（2014KTSCX031）：糖缀合物作为植物抗病诱导剂的设计合成及其作用机制研究。2015年1月-2017年12月，项目主持人。

7. 广州市“珠江科技新星”专项（201506010029）：基于细菌群体感应信号分子的抑制剂设计与合成及作物病害防控。2015年4月-2018年3月，项目主持人。

8. JSPS Postdoc Fellowship (P10100)：Molecular design, synthesis and bioactivity evaluation of novel glycosyl hydrazines. From the Japan Society for the Promotion of Science, Aug./2010 to Jul./2012，项目主持人。

学生获奖情况：

指导3名硕士研究生获得优秀毕业生称号

指导3名硕士研究生研究论文被评为优秀毕业论文；

指导本科生获得省级大学生创新创业训练计划项目一项，校级项目四项；

教学活动：

主讲研究生课程《微生物次生代谢小分子研究方法》、《植物保护研究进展》、《高级植物病理学》