国家优秀青年基金获得者(2020年)。在植物病原真菌细胞自噬的生物学功能及其上下游信号调控机制方面取得了系统性、创新性研究成果,首次报道真菌细胞铁死亡的生物学现象与功能。以第一/通讯(含共同)作者在Autophagy, Annual Review of Microbiology, PLoS Pathogens, New Phytologist, Journal of Integrative Plant Biology, Antioxidants&Redox Signaling等期刊发表学术论文30多篇。
研究领域:
以稻瘟病菌和甘蔗黑穗病菌为主要研究对象,围绕细胞自噬、蛋白乙酰化修饰系统、跨界化学通讯信号分子鉴定及其作用机理、环境信号应答等方面研究植物病原真菌致病机制。
学习经历:
1999.09 – 2003.07,中山大学生命科学学院 学士
2005.01 – 2011.01,新加坡国立大学生物科学学院 博士
工作经历:
2011.02- 2015.01 新加坡淡马锡生命科学研究所 博士后
2015.01 - 教授/ 研究员
代表性论文(2015年以来):
1. Meiling Liang#, Lihong Dong#, Yi Zhen Deng*. Circadian redox rhythm in plant-fungal pathogen interaction. Antioxid Redox Signal. 2022; doi: 10.1089/ars.2021.0281.
2.Lihong Dong#, Yuming Ma#, Cheng-Yen Chen, Lizheng Shen, Wenda Sun, Guobing Cui, Naweed I Naqvi*, Yi Zhen Deng*. Identification and Characterization of Auxin/IAA Biosynthesis Pathway in the Rice Blast Fungus Magnaporthe oryzae. J Fungi (Basel). 2022; 8(2):208.
3.Chaoxiang Lin, Xue Cao, Ziwei Qu, Shulin Zhang, Naweed I Naqvi*, Yi Zhen Deng*. The Histone Deacetylases MoRpd3 and MoHst4 Regulate Growth, Conidiation, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae. mSphere. 2021; 6(3):e0011821.
4.Meiling Liang#, Huijuan Ye#, Qing Shen#, Xianya Jiang, Guobing Cui, Wenxiang Gu, Lian-Hui Zhang*, Naweed I Naqvi*, Yi Zhen Deng*. Tangeretin inhibits fungal ferroptosis to suppress rice blast. J Integr Plant Biol. 2021; 63(12):2136-2149.
5.Qing Shen#, Meiling Liang#, Fan Yang, Yi Zhen Deng*, Naweed I Naqvi*. Ferroptosis contributes to developmental cell death in rice blast. New Phytol. 2020; 227(6):1831-1846.
6.Shulin Zhang#, Chaoxiang Lin#, Tian Zhou, Lian-Hui Zhang*, Yi Zhen Deng*. Karyopherin MoKap119-mediated nuclear import of cyclin dependent kinase regulator MoCks1 is essential for Magnaporthe oryzae pathogenicity. Cellular Microbiology. 2020; 22(1):e13114.
7.Yi Zhen Deng#*, Naweed Naqvi*. Metabolic Basis of Pathogenesis and Host Adaptation in Rice Blast. Annual Review of Microbiology. 2019; 73:601-619.
8.Meiling Liang#, Shulin Zhang#, Lihong Dong, Yanjun Kou, Chaoxiang Lin, Weijun Dai, Lian-Hui Zhang*, Yi Zhen Deng*. Label-Free Quantitative Proteomics of Lysine Acetylome Identifies Substrates of Gcn5 in Magnaporthe oryzae Autophagy and Epigenetic Regulation. mSystems. 2018; 3(6):e00270-18.
9.Shulin Zhang#, Meiling Liang#, Naweed I.Naqvi, Chaoxiang Lin, Wanqiang Qian, Lian-Hui Zhang*, Yi Zhen Deng*. Phototrophy and starvation-based induction of autophagy upon removal of Gcn5-catalyzed acetylation of Atg7 in Magnaporthe oryzae. Autophagy. 2017; 13(8): 1318-1330.
10.Yi Zhen Deng#, Ziwei Qu#, Naweed I Naqvi*. Twilight, a Novel Circadian-Regulated Gene, Integrates Phototropism with Nutrient and Redox Homeostasis during Fungal Development. PLoS Pathog. 2015; 11(6):e1004972.
科研项目:
目前主持2项自然科学基金项目、参与1项广东省重点领域研发计划项目;在研经费约190万元。