常长青

发布者：发布时间：2022-06-26浏览次数：191

　　植物病理学/微生物学研究员。先后涉足植物抗病（茉莉酸信号）、动物胚胎发育（肝脏发育、基因修复）、微生物群体感应及作物绿色栽培等多个研究方向。课题组目前主要以甘蔗、玉米和柑橘为研究对象，致力于：1）研究甘蔗鞭黑粉菌和玉米瘤黑粉菌的侵染致病机制，挖掘寄主的关键抗病基因，解析菌丝发育及侵染时与寄主植物的互作机制等；2）鉴定柑橘溃疡病菌、柑橘黄龙病菌的关键致病因子及群体感应信号，研发新型的信号淬灭菌/剂。自入职华农以来，以第一作者或通讯作者在PNAS, Environmental Microbiology, Journal of Fungi, Frontiers in Microbiology, BMC Genomics, Molecular Plant Pathology, Journal of Genetics and Genomics 等刊物发表研究论文多篇；第一发明人获国家发明专利授权十余项。先后主持过国家自然科学基金面上项目，973科技计划子课题，广东省、广州市自然科学基金、科技计划项目等多项。

研究领域：微生物遗传，植物病害防控

学习经历：

1995.09 - 199.06 湖南农业大学本科

1999.06 - 2002.06 硕士

2001.12 - 2002.05 新加坡分子农业生物研究院硕士联合培养

2008.09 - 2011.09 浙江大学博士

工作经历：

2002.09 - 2008.08 新加坡新科局分子细胞生物研究院，Assistant research officer, Research officer

2011.09 -2014.03 新加坡新科局分子细胞生物研究院，Research Fellow

2014.04 -2018.12 ，副教授

2019.01- ，研究员

社会兼职：

现任广东省微生物学会（第十届）理事

荣誉与奖励：

珠江人才计划第四批“群体微生物基础理论与前沿技术创新团队”。

第六届中国侨界贡献“创新团队”奖。

代表性论文及专利:

1.Kaihuai Li #, Jinxing Liao #, Ming Wei, Shanxu Qiu, Wu Weiyin, Yancun Zhao, Haihong Wang, Qiongguang Liu, Fengquan Liu * and Changqing Chang * (2022) The Xanthomonas citri reverse fitness deficiency by activating a novel β-glucosidase under low osmostress. Frontiers in Microbiology. doi: 10.3389/fmicb.2022.887967.

2.Enping Cai#, Shuquan Sun#, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang*, and Zide Jiang* (2021) Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1. Journal of Fungi. 7(8) 610. doi: 10.3390/jof7080610.

3.Enping Cai, Lingyu Li, Yizhen Deng, Shuquan Sun, Huan Jia, Rongrong Wu, Lianhui Zhang, Zide Jiang*, Changqing Chang*(2021) MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress. Environmental Microbiology. 23(6):3306-3317.

4.蔡恩平, 梅丹, 张小萌, 孙贤, 李玲玉, 吴熔熔, 邓懿祯, 姜子德*, 常长青* (2020) 甘蔗鞭黑粉菌原生质体转化DNA双片段的基因敲除方法的建立。菌物学报 22,39(12):2314-2327。

5.JinXing Liao#, KaiHuai Li#, JinPei Wang, JiaRu Deng, QiongGuang Liu, ChangQing Chang* (2019) RNA-seq analysis provides insights into the cold stress responses of Xanthomonas citri pv. citri. BMC genomics. 20 (1):807.

6.Chao Wang#, Fuzhou Ye#, Changqing Chang#, Xiaoling Liu, Jianhe Wang, Jinpei Wang, Xinfu Yan, Qinqin Fu, Jiannuan Zhou, Shaohua Chen, Yonggui Gao*, and Lianhui Zhang* (2019) Agrobacteria reprogram virulence gene expression by controlled release of host conjugated signals. PNAS. 116(44):22331-22340.（F1000评论）。

7.Changqing Chang #*, Cai Enping#, Deng Yizhen, Dan Mei, Shanxu Qiu, Baoshan Chen, Lian-Hui Zhang, Zide Jiang* (2019) cAMP/PKA Signaling Pathway Regulates Redox homeostasis essential for Sporisorium scitamineum Mating/Filamentation and Virulence. Environmental Microbiology. (3):959-971.

8.Shuquan Sun, Yizhen Deng, Enping Cai, Meixin Yan, Lingyu Li, Baoshan Chen, Changqing Chang*, Zide Jiang* (2019) The Farnesyltransferase β-Subunit Ram1 Regulates Sporisorium scitamineum Mating, Pathogenicity and Cell Wall Integrity. Frontiers in Microbiology. 8(10):976.doi: 10.3389/fmicb.2019.00976.

9.Jianuan Zhou#, Haibao Zhang#, Mingfa Lv, Yufan Chen, Lisheng Liao, Yingying Cheng, Shiyin Liu, Shaohua Chen, Fei He, Zining Cui, Zide Jiang, Changqing Chang*, Lianhui Zhang* (2016) SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol. Plant Pathology.17 (9) :1398-1408.

10.Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David Lane, Jinrong Peng* and ChenJun* (2015) p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Research. 25(3):351-69.

11.Ou Zhao#, Yin Le#, Changqing Chang#, Jinrong Peng*, Jun Chen* (2014) Protein Interaction Between p53 and Δ113p53 Is Required for the Anti-Apoptotic Function of Δ113p53. Journal of Genetics and Genomics. 41 (2):53-62.

12.Jasmine Lee, Je’en Wu, Yinyue Deng, Jing Wang, Chao Wang, Jianhe Wang, Changqing Chang, Yihu Dong, Paul Williams, Lianhui Zhang* (2013) A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology. 9(5):339-43. (F1000评论)。

13.Yinyue Deng#*, Nadine Schmid#, Chao Wang, Jianhe Wang, Gabriella Pessi, Donghui Wu, Jasmine Lee, Claudio Aguilar, Christian H. Ahrens, Changqing Chang, Haiwei Song, Leo Eber*, Zhang LH* (2012) Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover. PNAS. 109(38):15479-84.

14.Jingang Liu#, Lu Gong#, Chang Changqing#, Cong Liu, Jinrong Peng*, Jun Chen* (2012) Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish. Journal of Genetics and Genomics. 39(9):489-02.

15.Changqing Chang, Minjie Hu, Zhihui Zhu, Li Jan Lo, Jun Chen*, Jinrong Peng* (2011) liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish. PloS One. 6(8):e22910.

16.Jun Chen, Sok Meng Ng#, Changqing Chang#, Zhenhai Zhang, Jean Christophe Bourdon, Lane David P. Lane*, Jinrong Peng* (2009) p53 isoform ∆113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Dev. 23:278-290 (F1000评论)。

17.Fuquan Liu, Weimin Ni, Megan E.Griffith, Zhiyuan Huang, Changqing Chang, Wen Peng, Hong Ma*, Daoxin Xie* (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. The Plant Cell.16: 5-20.

18.常长青，邓嘉茹，姜子德，廖金星，陈少华，王金佩，蔡恩平。柑橘溃疡病菌产生小分子作为噻唑类杀菌剂增效剂在病害防治中的应用。专利号：ZL 201711152617.5。

19.常长青，廖金星，邓嘉茹，徐领会，刘冉淋，章婉贤。AHL分子作为化学农药杀菌增效剂在柑橘溃疡病防治中的应用。专利号：ZL 201810334632.X。

20.常长青，仇善旭，王雨婷，蔡恩平，沈荣晨，吴熔熔，李玲玉。一种纳米复合材料g-C3N4/Ni及其制备方法与应用。专利号：ZL 201811547445.6。

代表性科研项目 :

1.“广东省群体微生物基础理论与前沿技术创新团队”，珠江人才计划子课题，主持。

2.“柑橘溃疡病防控的新型杀菌增效剂研究”，广东省科技计划项目，主持。

3.“甘蔗鞭黑穗病菌有性配合信号系统的研究”， 973项目子课题，主持。

4.“一个新的C2H2锌指蛋白Rcm1调控甘蔗鞭黑粉菌有性配合的机理研究”，国家自然科学基金面上项目，主持。

5.“生物农药和杀虫剂生物合成关键技术研究与示范”，广东省重点领域研发计划，子课题主持。

6.“甘蔗鞭黑穗病生物防治技术的研发与应用”，广州市科技计划重点项目，子课题主持。

7.“膜泡蛋白SsDid4介导甘蔗鞭黑粉菌信息素信号转导的分子机制”，广东省自然科学基金项目，主持,（在研）。

8. “柑橘溃疡病菌PhoP蛋白调控离子信号在适应逆境及致病性中的作用研究”，广东省自然科学基金面上项目，主持（在研）。