长期致力于病原微生物研究，被认为是微生物群体感应领域的奠基者之一、群体淬灭防治微生物病害新理论的创建者。归国前任新加坡国立大学分子与细胞生物学院副教授、教授十余年；2012年回国后创建 群体微生物研究中心并担任主任；国务院学位委员会第七届植物保护学科评议组成员，入选国家杰出青年科学基金(海外)、国家重点人才工程等；曾获澳大利亚“博士后研究员奖”、新加坡“国家科学奖”等奖励。近五年先后主持国家973项目、广东省农业厅重大培育项目 、广东省重点领域研发计划等项目；担任广东省微生物学会副理事长，及多种国际刊物编委。近五年发表SCI论文60余篇，成果获F1000及刊物热点推荐。

研究领域：

群体感应；群体淬灭；柑橘黄龙病；木麻黄青枯病；水稻基腐病

学习经历：

1978.03-1982.02， （77级），获得学士学位 

1982.09-1985.07， （82级），获得硕士学位

1989.03-1993.03，澳大利亚亚德雷得大学，获得博士学位

工作经历：

1985.02 – 1989.02    植物病理系 助教

1993.03- 1997.05    澳大利亚昆士兰大学  博士后

1997.06 – 1998.06   澳大利亚维省植物生物工程中心 资深科学家/实验室主任

1998.06 – 2000.07   新加坡分子农业生物学院 资深科学家/首席研究员

2000.08 -2002.07    新加坡分子农业生物学院 副教授/首席研究员

2002.08- 2009.03    新加坡分子与细胞生物学院 副教授/首席研究员

2009.04- 2011.10    新加坡分子与细胞生物学院 教授/实验室主任

2011.11- 2016.09    植物病理系 教授

2016.10--                群体微生物研究中心 教授/中心主任

社会、学会或学术兼职：

2006年2月被聘为 植物病理学学科教育部重大人才奖励计划特聘教授

2011年入选亚太国际分子生物技术网络成员 

2011年为广东省第二批“领军人才”特聘教授

担任Annual Review of Microbiology 、Molecular Plant-Microbe Interactions 等国际期刊编委

荣誉与奖励：

2018 中国植物病理学会会士

2018 广州市荣誉市民

2017 美国微生物学院院士

2016 中国侨界贡献奖-创新团队

2015 “十二五”十佳科研创新团队

2014 国家重点基础研究项目（973项目），首席科学家

2012 国家特聘专家

2012 广东省科研创新领军人才

2009 新加坡科技局科技转化旗舰奖

2005 新加坡国家科学奖

2002 新加坡国立大学卓越研究员奖

2001 国家杰出青年科学基金(海外)

2001 亚太国际分子生物技术网络会士

1996 澳大利亚研究理事会博士后研究员基金获得者

近五年代表性论文：

1.Chen, Y. ,  Lv, M. ,  Liang, Z. ,  Liu, Z. ,  Zhou, J. , &  Zhang, L. H. . (2022). Cyclic di-gmp modulates sessile-motile phenotypes and virulence in dickeya oryzae via two pilz domain receptors. Molecular Plant Pathology.

2.Lv, M., Chen, Y., Hu, M., Yu, Q., Duan, C., Ye, S., ... & Zhang, L. (2022). OhrR is a central transcriptional regulator of virulence in Dickeya zeae. Molecular plant pathology, 23(1), 45-59.

3.Chen, Y., Zhou, J., Lv, M., Liang, Z., Parsek, M. R., & Zhang, L. H. (2020). Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in Dickeya zeae EC1. Mbio, 11(6), e02993-20.

4.Huang, Y., Chen, Y., & Zhang, L. H. (2020). The roles of microbial cell-cell chemical communication systems in the modulation of antimicrobial resistance. Antibiotics, 9(11), 779.

5.Ye F, Wang C, Fu Q, Yan XF, Bharath SR, Casanas A, Wang M, Song H, Zhang LH*, Gao YG*(2020). Structural basis of a novel repressor, SghR, controlling Agrobacterium infection by cross-talking to plants. Journal of Biological Chemistry, 295(34), 12290-12304.

6.Pan Li, Jianzhao Huang, Nan Xiao, Xin Cai, Yunyun Yang, Jiewei Deng, Lian-Hui Zhang, Bing Du. (2020). Sacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats. Food & Function, 11(7), 5827-5841.

7.Qishun Feng, Stephen Dela Ahator, Tian Zhou, Zhiqing Liu, Qiqi Lin, Yang Liu, Jiahui Huang, Jianuan Zhou and Lian-Hui Zhang (2020) Regulation of Exopolysaccharide Production by ProE, a Cyclic-Di-GMP Phosphodiesterase in Pseudomonas aeruginosa PAO1. Frontiers in Microbiology 11: 1226.

8.Huishan Wang, Lisheng Liao, Shaohua Chen, Lian-Hui Zhang (2020) A Quorum Quenching Bacterial Isolate Contains Multiple Substrate-Inducible Genes Encoding for Degradation of Diffusible Signal Factor. Applied and Environmental Microbiology 86(7): e02930-19.

9.Xianfa Meng, Stephen Dela Ahator, Lian-Hui Zhang (2020) Molecular Mechanisms of Phosphate Stress Activation of Pseudomonas aeruginosa Quorum Sensing Systems. mSphere 5(2): e00119-20.

10.Shiyin Liu, Fei He, Nuoqiao Lin, Yumei Chen, Zhibin Liang, Lisheng Liao, Mingfa Lv, Yufan Chen, Shaohua Chen, Jianuan Zhou, and Lian-Hui Zhang (2020) Pseudomonas sp. ST4 produces variety of active compounds to interfere fungal sexual mating and hyphal growth. Microbial Biotechnology 13(1): 107-117.

11.Wang J, Wang J, Zhang LH (2020) Immunological blocking of spermidine-mediated host-pathogen communication provides effective control against Pseudomonas aeruginosa infection. Microbiol Biotech 13(1): 87-96.

12.Xiao-bing Song, Ai-tian Peng, Jin-feng Ling, Yi-ping Cui, Bao-ping Cheng, Lian-hui Zhang (2019) Composition and change in the microbiome of Diaphorina citri infected with Candidatus Liberibacter asiaticus in China. International Journal of Tropical Insect Science Volume 39, Issue 4, pp 283–290.

13.Si-ChengXing, Jian-DuiMi, Jing-YuanChen, LeiXiao, Yin-BaoWu, Juan BooLiang, Lian-HuiZhang, Xin-DiLiao (2019) Themetabolismand morphology mutation response of probiotic Bacillus coagulans for lead stress. Science of the Total Environment Volume 693, 25, 133490.

14.Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH, (2019) Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. P Natl Acad Sci USA. 116(44): 22331-22340.

15.Shulin Zhang, Chaoxiang Lin, Tian Zhou, Lian-Hui Zhang, Yi Zhen Deng (2019) Karyopherin MoKap119-mediated nuclear import of cyclin dependent kinase regulator MoCks1 is essential for Magnaporthe oryzae pathogenicity. Cellular Microbiology 22(1): e13114.

16.Zurong Shi, Qingwei Wang, Yasheng Li, Zhibing Liang, Linghui Xu, Jianuan Zhou, Zining Cui and Lian-Hui Zhang (2019) Putrescine is an intraspecies and interkingdom cell-cell communication signal modulating the virulence of Dickeya zeae. Frontiers in Microbiology 10: 1950.

17.张炼辉 (2019) 微生物群体感应系统的研究进展 学报. 40(5): 50-58.

18.Wang J, Wang C, Yu HB, Dela Ahator S, Wu XY, Lv S, Zhang LH. (2019) Bacterial quorum sensing signal IQS induces host cell apoptosis by targeting POT1-p53 signalling pathway. Cellular Microbiology 21(10): e13076.

19.Dela Ahator S, Zhang L. (2019) Small Is Mighty-Chemical Communication Systems in Pseudomonas Aeruginosa. Annual Review of Microbiology 73: 559-578.

20.Lv M, Hu M, Li P, Jiang Z, Zhang LH, Zhou J (2019) A two-component regulatory system VfmIH modulates multiple virulence traits in Dickeya zeae. Molecular microbiology 111(6): 1493-1509.

21.Liang Z, Huang L, He F, Zhou X, Shi Z, Zhou J, Chen Y, Lv M, Chen Y, Zhang LH (2019) A Substrate-Activated Efflux Pump, DesABC, Confers Zeamine Resistance to Dickeya zeae. Mbio 10(3): e00713-19.

22.Wang Y, Deng YZ, Cui G, Huang C, Zhang B, Chang C, Jiang Z, Zhang LH. (2019) The AGC Kinase SsAgc1 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity. mSphere 4(3): e00259-19.

23.Cheng Y, Yam JKH, Cai Z, Ding Y, Zhang LH, Deng Y, Yang L (2019) Population dynamics and transcriptomic responses of Pseudomonas aeruginosa in a complex laboratory microbial community. NPJ Biofilms Microbiomes 5:1. 

24.Liang M, Zhang S, Dong L, Kou Y, Lin C, Dai W, Zhang LH, Deng YZ (2018) Label-Free Quantitative Proteomics of Lysine Acetylome Identifies Substrates of Gcn5 in Magnaporthe oryzae Autophagy and Epigenetic Regulation. Msystems 3(6): e00270-18.

25.Hu M, Li J, Chen R, Li W, Feng L, Shi L, Xue Y, Feng X, Zhang LH, Zhou J (2018) Dickeya zeae strains isolated from rice, banana and clivia rot plants show great virulence differentials. BMC MICROBIOL 18 (1).

26.Zhang S, Deng YZ, Zhang LH (2018) Phytohormones: the chemical language in Magnaporthe oryzae-rice pathosystem. Mycology 9: 233-237.

27.Chen YM, Dong YH, LiangZB, Zhang LH, Deng YZ (2018) Enhanced vascular activity of a new chimeric promoter containing the full CaMV 35S promoter and the plant xylogen protein 1 promoter. 3 Biotech 8: 380.

28.Cui C, Yang C, Song S, FU S, Sun X, Yang L, He F, Zhang LH, Zhang Y, Deng Y (2018) A novel two-componernt system modulates quorum sensing and pathogenicity in Burkholederia cenocepacia. Mol Microbiol 108: 32-44.

29.Yang C, Cui C, Ye Q, Kan J, Fu S, Song S, Huang Y, He F, Zhang LH, Jia YT, Gao YG, Harwood CS, Deng Y (2017) Burkholderia cenocepacia integratescis-2-dedecenoic acid and cyclic dimeric guanosine monophosphate signals to control virulence. PNAS 114(49): 13006-13011.

30.Zhang S, Liang M, Naqvi NI, LinC, QianW, Zhang LH, Deng YZ (2017) Phototrophy and starvation-based induction of autophagy upon removal of Gcn5-catalyzed acetylation of Atg7 in Magnaporthe oryzae. Autophagy 13(8): 1318-1330. 

31.Liu SY, Lin NQ, Chen YM, Liang ZB, Liao LS, Lv MF, Chen YF, Tang YX, He F, Chen SH, Zhou JN and Zhang LH (2017) Biocontrol of Sugarcane Smut Disease by Interference of Fungal Sexual Mating and Hyphal Growth Using a Bacterial Isolate. Front Microbiol 8: 778.

32.Li P, Yin W, Yan J, Chen Y, Fu S, Song S, Zhou J, Lyn M, Deng Y, Zhang LH (2017) Modulation of inter-kingdom communication by PhcBSR quorum sensing system in Ralstonia solanacearum phylotype I strain GMI1000. Front Microbiol 8: 1172.

33.Zhou L, Zhang LH, Cámara M, He YW (2017) The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends Microbiol 25(4): 293-303.

34.Li YS, Hu DK, Zhao DS, Liu XY, Jin HW, Song GP, Cui ZN, Zhang LH (2017) Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors. Bioorg Med Chem 25(6): 1852-1859. 

35.Meixin Yan, Enping Cai, Jianuan Zhou, Changqing Chang, Pinggen Xi, Wankuan Shen, Lingyu Li, Zide Jiang, Yi Zhen Deng, Lian-Hui Zhang (2016) A Dual-Color Imaging System for Sugarcane Smut Fungus Sporisorium scitamineum. Plant Disease 100(12): 2357-2362.

36.Chao Wang, Desong Tang, Yong-Gui Gao, Lian-Hui Zhang (2016) Succinic Semialdehyde Promotes Prosurvival Capability of Agrobacterium tumefaciens. Journal of Bacteriology 198(6): 930-40.

37.Yinyue Deng, Jien Wu, Wenfang Yin, Peng Li, Jianuan Zhou, Shaohua Chen, Fei He, Jun Cai, Lian-Hui Zhang (2016) Diffusible signal factor family signals provide a fitness advantage to Xanthomonas campestris pv.campestris in interspecies competition. Environmental Microbiology 18(5): 1534-45.

38.Meixin Yan, Weijun Dai, Enping Cai, Yi Zhen Deng, Changqing Chang, Zide Jiang, Lian-Hui Zhang (2016) Transcriptome analysis of Sporisorium scitamineum reveals critical environmental signals for fungal sexual mating and filamentous growth. BMC Genomics 17: 354.

39.Peng Li, Dechen Wang, Jinli Yan, Jianuan Zhou, Yinyue Deng, Zide Jiang, Bihao Cao, Zifu He, Lianhui Zhang (2016) Genomic Analysis of Phylotype I Strain EP1 Reveals Substantial Divergence from Other Strains in the Ralstonia solanacearum Species Complex. Frontiers in Microbiology 7: 1719.

40.Wang C, McPherson JR, Zhang LH, Rozen S, Sabapathy K (2016) Transcription-associated mutation of lasR in Pseudomonas aeruginosa. DNA Repair 46: 9-19. 

41.Zhou JN, Zhang HB, Lv MF, Chen YF, Liao LS, Cheng YY, Liu SY, Chen SH, He F, Cui ZN, Jiang ZD, Chang C, Zhang LH (2016) SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol Plant Pathol  17:1398-1408.

42.Lin B, Zhuo K, Chen S, Hu L, Sun L, Wang X, Zhang LH, Liao J (2016) A novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system. New Phytol 209: 1159-1173.