胡伟慧
姓名：胡伟慧
职务：教师
联系方式：whuaf@connect.ust.hk; huweihui@scau.edu.cn
个人简介
胡伟慧，女，山东菏泽人，博士。主要研究方向：海洋生物活性成分在心血管方面的应用；传统中药非药用部位在绿色水产养殖方面的应用；传统中药活性物质的开发利用。近年来，主持省级项目1项，发表SCI 学术论文20 余篇，其中以第一作者发表SCI 学术论文9 篇，申请发明专利2 项。
工作经历
2020.06-至今 海洋学院 讲师
2019.10-2020.06 香港科技大学生命科学学院 Research associate
教育经历
2016.09-2019.08 香港科技大学生命科学学院 博士
2013.09-2016.06 沈阳药科大学药学院 硕士
2009.09-2013.06 山东中医药大学药学院 学士
科研项目：
主持项目：
基于海洋芯片筛选平台的海洋生物酚类活性药物成分的开发利用 （广东省基础与应用基础区域联合基金-青年基金项目）
参与项目：
1、以HerboChips®技術從中藥中鑑定具有血管內皮生長因子結合特性的活性成分: 研發控制血管生成天然藥物，香港特别行政区创新科技署，2016/09-2019/09，参与；
2、开发含有中药活性成分的新一代水产饲料-减少抗生素在饲养业的使用量，香港特别行政区创新科技署，2019/01-2021/01，参与；
3、虎杖苷及其类似物对老年黄斑病变的治疗功效，香港特别行政区创新科技署，2019/08-2021/08，参与；
4、中药丹参的化学模式识别研究，深圳市基础研究计划基础研究项目，2013/12-2016/12，参与；
5、安神类保健食品中非法添加化学成分的快速检测方法开发，深圳市基础研究项目，2012/6-2015/6，参与
代表性论文：
[1] Weihui Hu, Diana Kun Dai, Brody Zhongyu Zheng, Ran Duan, Gallant Kar Lun Chan, Tina Tingxia Dong, Qiwei Qin, Karl Wah-Keung Tsim. The binding of kaempferol-3-O-rutinoside to vascular endothelial growth factor potentiates anti-inflammatory efficiencies in lipopolysaccharide-treated mouse macrophage RAW264.7 cells. Phytomedicine 2021, 80: 153400.
[2] Weihui Hu, Diana Kun Dai, Brody Zhongyu Zheng, Ran Duan, Tina Tingxia Dong, Qiwei Qin, Karl Wah-Keung Tsim. Piceatannol, a natural analog of resveratrol, exerts anti-angiogenic effciencies by blockage of vascular endothelial growth factor binding to its receptor. Molecules 2020, DOI: 10.3390/molecules25173769.
[3] Weihui Hu†, Shing-Hung Mak†, Brody Zhongyu Zheng, Ying-Jie Xia, Miranda Li Xu, Ran Duan, Tina Tingxia Dong, Shaoping Li, Changsen Zhan, Xiaohui Shang, Karl Wah-Keung Tsim. Shexiang Baoxin Pill, a traditional Chinese herbal formula, rescues the cognitive impairments in APP/PS1 transgenic mice. Frontiers in pharmacology 2020, doi: 10.3389/fphar.2020.01045.
[4] Weihui Hu†, Huaiyou Wang †, Kun Dai, Zhongyu Zheng, Qingping Xiong, Tingxia Dong, Ran Duan, Gallant Kar Lun Chan, Wenchuan Bi, Karl Wah-Keung Tsim. Kaempferol, a major flavonoid in Ginkgo Folium, binds to vascular endothelial growth factor and potentiates angiogenic functions in cultured endothelial cells. Frontiers in pharmacology 2020, doi: 10.3389/fphar.2020.00526.
[5] Weihui Hu, Huaiyou Wang, Ran Duan, Xiangpeng Kong, Gallant Kar Lun Chan, Qingping Xiong, Tingxia Dong, Karl Wah-Keung Tsim. Synergy of ginkgetin and resveratrol in suppressing VEGF-induced angiogenesis: a therapy in treating colorectal cancer. Cancers 2019, 11(12), 1828.
[6]Weihui Hu, Huaiyou Wang, Xiangpeng Kong, Qingping Xiong, Karman Ka Man Poon, Li Xu, Ran Duan, Gallant Kar Lun Chan, Tingxia Dong, Karl Wah-Keung Tsim. Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signalling. FASEB Journal 2019, 33: 532-544.
[7] Weihui Hu, Ran Duan, Yiteng Xia, Qingping Xiong, Huaiyou Wang, Gallant Kar Lun Chan, Siyue Liu, Tingxia Dong, Qiwei Qin, Karl Wah-Keung Tsim. Binding of resveratrol to vascular endothelial growth factor (VEGF) suppresses angiogenesis by inhibiting the receptor signalling. Journal of Agricultural and Food Chemistry 2019, 67: 1127-1137.
[8] Weihui Hu, Gallant Kar Lun Chan, Jianshu Lou, Qiyun Wu, Huaiyou Wang, Ran Duan, Michael Yu Tung Cheng, Tingxia Dong, Karl Wah-Keung Tsim. The extract of Polygoni Cuspidati Rhizoma et Radix suppresses the vascular endothelial growth factor-induced angiogenesis. Phytomedicine 2018, 42: 135-143.
[9] Qingping Xiong †, Zhuoyue Song†, Weihui Hu†, Liang Jian, Yi Jing, Lian He, Song Huang, Xiaoli Wang, Shaozhen Hou, Tingting Xu, Jing Chen, Danyan Zhang, Yingying Shi, Hailun Li, Shijie Li. Methods of extraction, separation, purification, structural characterization for polysaccharides from aquatic animals and their major pharmacological activities. Critical Reviews in Food Science and Nutrition 2018, 1: 1-9.
[10] Yiteng Xia, Gallant Kar-Lun Chan, Huaiyou Wang, Tina Tingxia Dong, Ran Duan, Weihui Hu, Qiwei Qin, Wenxiong Wang, Karl Wah-Keung Tsim. The anti-bacterial effects of aerial parts of Scutellaria baicalensis: Potential application as an additive in aquaculture feedings. Aquaculture 2020, 526: 735418.
[11] Yiteng Xia, Weihui Hu, Qiyun Wu, Tina Tingxia Dong, Ran Duan, Jian Xiao, Shaoping Li, Qiwei Qin, Wenxiong Wang, Karl Wah-Keung Tsim. The herbal extract deriving from aerial parts of Scutellaria baicalensis shows anti-inflammation and anti-hypoxia responses in cultured fin cells from rabbit fish. Fish & Shellfish Immunology 2020, 106: 71-78.
