一、个人基本资料
姓名：乐学义
性别：男
出生年月：1961.07
籍贯：湖北武穴
二、联系方式
邮箱：lexy@scau.edu.cn
通讯地址：广州市 材料与能源学院
邮编：510642
三、个人简述
博士, 教授，博/硕士研究生导师。中国化学会终身会员,兼任广东省化工学会副理事长、广东省化学会常务理事、广东省高等学校化工委员会理事、《 学报》及《广东化工》编委等。长期从事生物无机化学、药物化学、食品科学等交叉学科研究,先后承担省部级以上科研项目20余项,已公开发表学术论文180多篇,其中90余篇被SCI收录,获得国家发明专利2项,作为主要参加人获广东省自然科学一等奖1项,合作出版编著1本。
四、教育背景
1978/09-1982/07, 湖北师范大学化学系本科生
1985/09-1988/06, 华中师范大学化学系硕士研究生
1993/09-1996/06, 中山大学化学化工学院博士研究生
五、工作经历
1982/08-1985/08, 湖北省应城市教师进修学校化学教师
1988/06-1993/08, 湖北工程学院化学系讲师
1996/07-1997/12, 理学院讲师
1997/12-2001/12, 理学院副教授、硕士研究生导师(1999/06-)，期间担任应用化学系副主任(2001/03-2001/04) 、理学院副院长兼任应用化学系主任（2001/05- 2006/12）
2001/12-2014/12， 理学院教授(破格)、博士研究生导师(2005/06-)，期间担任理学院院长（2007/01-2014/12）
2015/01-现在, 材料与能源学院应用化学系教授
六、科研方向
具有抗菌、抗肿瘤等活性的化学新药研制与开发；具有抗氧化、抗菌等功能性作用的食品保鲜剂及添加剂的研究与应用；仿生材料及生物质材料的研究与应用。
七、代表性科研论文
1．Yong-Yu Qi, Qian Gan , Ya-Xian Liu, Ya-Hong Xiong, Zong-Wan Mao, Xue-Yi Le*. Two new Cu(II) dipeptide complexes based on 5-methyl-2-(
2．Chun-Lian Zhang, Ya-Xian Liu, Xue-Mei Zhang, Shi Chen, Fang Shen, Ya-Hong Xiong, Wei Liu,, Zong-Wan Mao, Xue-Yi Le*. Synthesis, characterization, DNA/HSA interactions and in vitro cytotoxic activities of two novel water-soluble copper(II) complexes with 1,3,5-triazine derivative ligand and amino acids. Materials Science & Engineering C, 2018, 91,414-425.
3．Yujia Liu, Danyang Ying, Luz Sanguansri, Yanxue Caib, Xueyi Le*. Adsorption of catechin onto cellulose and its mechanism study: Kinetic models, characterization and molecular simulation. Food Research International, 2018, 12, 225-232.
4．Yujia Liu, Yanxue Cai, Danyang Ying, Yinlian Fu, Yahong Xiong, Xueyi Le*. Ovalbumin as a carrier to significantly enhance the aqueous solubility and photostability of curcumin: Interaction and binding mechanism study. International Journal of Biological Macromolecules, 2018, 116, 893–900.
5．Chunlian Zhang, Xuemei Zhang,Wei Liu, Shi Chen*, Zong-Wan Mao, Xue-Yi Le*. Synthesis, crystal structures and DNA/human serum albumin binding of ternary Cu(II) complexes containing amino acids and 6‐(pyrazin‐2‐yl)‐1,3,5‐triazine‐2,4‐diamino. Appllied Organometallic Chemistry, 2018,32(2) , DOI: 10.1002/aoc.3994.
6．Yongyu Qi, Yaxian Liu, Qian Gan, Yahong Xiong, Zongwan Mao, Xueyi Le*. Three new mixed‐ligand copper(II) complexes containing glycyl‐L‐valine and N,N‐aromatic heterocyclic compounds: Synthesis, characterization, DNA interaction, cytotoxicity and antimicrobial activity. Appllied Organometallic Chemistry, 2018,32(3) , DOI: 10.1002/aoc.4126.
7．Fang Shen,Yaxian Liu,Shumin Li,Chikun Jiang,Bingfeng Wang, Yahong Xiong*, Zongwan Mao,Xueyi Le*, Synthesis, crystal structures, molecular docking and in vitro cytotoxicity studies of two new copper(II) complexes: special emphasis on their binding to HAS, New Journal of Chemistry, 2017, 41, 12429-12441.
8．Yujia Liu, Danyang Ying, Yanxue Cai, Xueyi Le*, Improved antioxidant activity and physicochemical properties of curcumin by adding ovalbumin and its structural characterization. Food Hydrocolloids, 2017,72, 304-311.
9．Qian Gan, Chun-Lian Zhang, Bing-Feng Wang, Ya-Hong Xiong, Zong-Wan Mao, Xueyi Le*. Two new mixed copper(II)–dipeptide complexes of N,N-donor heterocycle ligands: studies on their non-covalent DNA binding, chemical nuclease, antioxidant and anticancer activities. RSC Advances, 2016, 6, 35952-35965.
10．Yujia Liu, Yanxue Cai, Xueying Jiang, Jinping Wu, Xueyi Le*. Molecular interactions, characterization and antimicrobial activity of curcumin-chitosan blend films. Food Hydrocolloids, 2016, 52, 564-572.
11．Xia-Bing Fu, Jia-Jia Zhang, Dan-Dan Liu, Qian Gan, Hong-Wei Gao, Zong-Wan Mao, Xue-Yi Le*. Cu(II)–dipeptide complexes of 2-(4′-thiazolyl)benzimidazole: Synthesis, DNA oxidative damage, antioxidant and in vitro antitumor activity. Journal of Inorganic Biochemistry, 2015, 143, 77-87.
12．Yujia Liu, Dandan Liu, Li Zhu, Qian Gan, Xueyi Le*,Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome. Food Research International, 2015, 74, 97-105.
13．Xia-Bing Fu, Dan-Dan Liu, Yuan Lin, Wei Hu, Zong-Wan Mao and Xue-Yi Le*. Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions.
14．Xia-Bing Fu, Gui-Tian Weng, Dan-Dan Liu, Xue-Yi Le*, Synthesis, characterization, DNA binding and cleavage, HAS interaction and cytotoxicity of a new copper(II) complex derived from 2-(
15．Wei Hu, Suwen Deng, Jianyin Huang, Yanmei Lu, Xueyi Le*, Wenxu Zheng*. Intercalative interaction of asymmetric copper(II) complex with DNA: Experimental, molecular docking, molecular dynamics and TDDFT studies.Journal of Inorganic Biochemistry, 2013,127, 90-98.
八、主持科研项目
1．高抗氧化活性黄酮类金属配合物研制及应用.广东省科技计划项目，2017/01 - 2019/12
2．新型靶向TopoⅠ铜配合物的设计合成及其抗肿瘤活性. 广东省自然科学基金面上项目，2015/08-2018/08
3．双胍基化壳聚糖研制及其涂膜保鲜水果研究.广东省科技计划项目，2012/01-2014/12
4．新型靶向抗菌配合物的设计、合成及生物活性研究.广东省自然科学基金面上项目，2010/10-2012/10
5．新型α-氨基酸-金属离子-苯并咪唑衍生物复合抗菌剂的研制及其应用. 广东省科技计划项目，2009/07-2012/06
九、获奖情况
1．“混配配合物的生物功能、作用机制及其应用探索”于1996年获广东省自然科学一等奖（排名第九）
2． 国邦助教奖(1999年)
3． 科学研究先进工作者(2001年)
4．广东省“千百十工程”校级学术骨干培养对象先进个人(2002年)
5． “三育人”先进个人(2014年)
